Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension.

Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Research Abstract Details 

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Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Abstract Text:

Isidore C Okere,Martin E Young,Tracy A McElfresh,David J Chess,Victor G Sharov,Hani N Sabbah,Brian D Hoit,Paul Ernsberger,Margaret P Chandler,William C Stanley,

The effects of dietary fat intake on the development of left ventricular hypertrophy and accompanying structural and molecular remodeling in response to hypertension are not understood. The present study compared the effects of a high-fat versus a low-fat diet on development of left ventricular hypertrophy, remodeling, contractile dysfunction, and induction of molecular markers of hypertrophy (ie, expression of mRNA for atrial natriuretic factor and myosin heavy chain beta). Dahl salt-sensitive rats were fed either a low-fat (10% of total energy from fat) or a high-fat (60% of total energy from fat) diet on either low-salt or high-salt (6% NaCl) chow for 12 weeks. Hearts were analyzed for mRNA markers of ventricular remodeling and activities of the mitochondrial enzymes citrate synthase and medium chain acyl-coenzyme A dehydrogenase. Similar levels of hypertension were achieved with high-salt feeding in both diet groups (systolic pressure of approximately 190 mm Hg). In hypertensive rats fed low-fat chow, left ventricular mass, myocyte cross-sectional area, and end-diastolic volume were increased, and ejection fraction was decreased; however, these effects were not observed with the high-fat diet. Hypertensive animals on low-fat chow had increased atrial natriuretic factor mRNA, myosin heavy chain isoform switching (alpha to beta), and decreased activity of citrate synthase and medium chain acyl-coenzyme A dehydrogenase, which were all attenuated by high-fat feeding. In conclusion, increased dietary lipid intake can reduce cardiac growth, left ventricular remodeling, contractile dysfunction, and alterations in gene expression in response to hypertension.

Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Publishing Authors By Initials

IC Okere,ME Young,TA McElfresh,DJ Chess,VG Sharov,HN Sabbah,BD Hoit,P Ernsberger,MP Chandler,WC Stanley,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: ventricular function: ventricular remodeling research

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Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Hypertension

VOLUME: 48

Page Numbers: 1116-23

Journal Abbreviation: Hypertension

ISSN: 1524-4563

DAY: 23

MONTH: 10

YEAR: 2006

Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7906255

Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Keywords Mesh Terms:

KEYWORDS: Ventricular Remodeling

MESH TERMS: physiology

Chemical & Substance for Abstract: Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension. Information

Substance Name: Atrial Natriuretic Factor

Registry Number: 85637-73-6

Grant and Affiliation Information for Low carbohydrate/high-fat diet attenuates cardiac hypertrophy, remodeling, and altered gene expression in hypertension.

AFFILIATION: Department of Physiology and Biophysics, Case Western Reserve University, Cleveland, OH 44106-4970, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL074259

ACRONYM: HL

MEDLINETA: Hypertension

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