Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy.

Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy. Research Abstract Details 

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Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy. Abstract Text:

Ann-Charlott ,Per Magnusson,Anne-Christine Hlander, Karlsson,Anna-Karin Kroksmark, Tulinius,Diana Swolin-Eide,Ann-Charlott ,Per Magnusson,Anne-Christine Ahlander, Karlsson,Anna-Karin Kroksmark, Tulinius,Diana Swolin-Eide,

This cross-sectional study examined bone mineral density, bone turnover, body composition and calciotropic hormones in 24 boys with Duchenne muscular dystrophy (DMD) (2.3-19.7 years), most of whom were being treated with prednisolone, and 24 age-matched healthy boys. Our study demonstrated lower bone mineral density in the DMD group for total body, spine, hip, heel and forearm measurements. These differences between DMD patients and controls increased with increasing age. Biochemical markers of both bone formation and resorption revealed reduced bone turnover in DMD patients. The fracture rate was not higher in DMD patients. The DMD group had low vitamin D levels but high leptin levels in comparison with the control group. Muscle strength correlated with bone mineral density assessed at the hip and heel in the DMD group. Interventions that increase bone formation should be considered, as DMD patients have reduced bone turnover in addition to their low bone mineral density.

Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy. Publishing Authors By Initials

AC ,P Magnusson,AC Hlander,J Karlsson,AK Kroksmark,M Tulinius,D Swolin-Eide,AC ,P Magnusson,AC Ahlander,J Karlsson,AK Kroksmark,M Tulinius,D Swolin-Eide,

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Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Neuromuscular disorders : NMD

VOLUME: 17

Page Numbers: 919-28

Journal Abbreviation: Neuromuscul. Disord.

ISSN: 0960-8966

DAY: 12

MONTH: 07

YEAR: 2007

Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy. Information

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LANGUAGE: eng

NlmUniqueID: 9111470

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Grant and Affiliation Information for Low bone mineral density and decreased bone turnover in Duchenne muscular dystrophy.

AFFILIATION: Department of Orthopaedics, Institute of Clinical Sciences, Sahlgrenska University Hospital/Ostra, Sahlgrenska Academy at Göteborg University, SE-416 85 Göteborg, Sweden.

Country: England

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MEDLINETA: Neuromuscul Disord

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