Lovastatin induces apoptosis in a metastatic ovarian tumour cell line.

Lovastatin induces apoptosis in a metastatic ovarian tumour cell line. Research Abstract Details 

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Lovastatin induces apoptosis in a metastatic ovarian tumour cell line. Abstract Text:

Z Han,J H Wyche,

Lovastatin is a very specific and potent inhibitor of 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase, which regulates a rate-limiting step in the cellular synthesis of isoprenoid and cholesterol. In this study, we demonstrate that treatment of rat ovarian metastatic OV1N cells with lovastatin induces apoptosis. Furthermore, apoptotic death of lovastatin-treated OV1N cells can be prevented by the addition of either mevalonic acid (an immediate metabolite of HMG-CoA) or farnesyl pyrophosphate (one of the downstream products of mevalonic acid metabolism). However, metabolic derivatives of farnesyl pyrophosphate failed to prevent the apoptotic effect of lovastatin on cells. Therefore farnesyl pyrophosphate appears to be important for cell survival and the relationship of this compound to protein farnesylation and apoptosis induction is discussed.

Lovastatin induces apoptosis in a metastatic ovarian tumour cell line. Publishing Authors By Initials

Z Han,JH Wyche,

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Lovastatin induces apoptosis in a metastatic ovarian tumour cell line. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Cell death and differentiation

VOLUME: 3

Page Numbers: 223-8

Journal Abbreviation: Cell Death Differ.

ISSN: 1350-9047

DAY: 20

MONTH: Apr

YEAR: 1996

Lovastatin induces apoptosis in a metastatic ovarian tumour cell line. Information

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LANGUAGE: eng

NlmUniqueID: 9437445

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AFFILIATION: Department of Molecular Biology, Cell Biology, and Biochemistry, Brown University, Providence, RI.

Country: England

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MEDLINETA: Cell Death Differ

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