Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition.

Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Research Abstract Details 

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Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Abstract Text:

Gopal Dhar,Smita Mehta,Snigdha Banerjee,Ashleigh Gardner,Bryan M McCarty,Sharad C Mathur,Donald R Campbell,Suman Kambhampati,Sushanta K Banerjee,

The objective of this study was to explore the pathophysiological relevance of WISP-2/CCN5 in progression of human pancreatic adenocarcinoma (PAC). We found WISP-2/CCN5 mRNA and protein expression was faint and sporadic in PAC and detected in only 8.7-20% of the samples with varying grades as compared to adjacent normal and chronic pancreatitis samples where expression was very high in the ducts and acini. Colocalization studies in tissue-microarray slides revealed WISP-2/CCN5 mRNA loss was associated with p53 overexpression in PAC. Like tissue samples, p53 mutant-PAC cell lines show loss of WISP-2/CCN5. Moreover, functional analysis studies demonstrate exposure of pancreatic cancer cells to WISP-2/CCN5 recombinant protein enhances mesenchymal-epithelial-transition (MET). Collectively, we suggest WISP-2/CCN5 silencing may be a critical event during differentiation and progression of PAC and mutant p53 is possibly an important player in pursuing this episode.

Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Publishing Authors By Initials

G Dhar,S Mehta,S Banerjee,A Gardner,BM McCarty,SC Mathur,DR Campbell,S Kambhampati,SK Banerjee,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Cancer letters

VOLUME: 254

Page Numbers: 63-70

Journal Abbreviation: Cancer Lett.

ISSN: 0304-3835

DAY: 26

MONTH: 03

YEAR: 2007

Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Information

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LANGUAGE: eng

NlmUniqueID: 7600053

Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: metabolism

Chemical & Substance for Abstract: Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition. Information

Substance Name: WISP2 protein, human

Registry Number: 0

Grant and Affiliation Information for Loss of WISP-2/CCN5 signaling in human pancreatic cancer: a potential mechanism for epithelial-mesenchymal-transition.

AFFILIATION: Cancer Research Unit, VA Medical Center, Kansas City, MO 64128, USA.

Country: Ireland

AGENCY: United States NCRR

GRANT: 1 P20 RR15563

ACRONYM: RR

MEDLINETA: Cancer Lett

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