Loss of suppressor-of-fused function promotes tumorigenesis.

Loss of suppressor-of-fused function promotes tumorigenesis. Research Abstract Details 

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Loss of suppressor-of-fused function promotes tumorigenesis. Abstract Text:

Y Lee,R Kawagoe,K Sasai,Y Li,H R Russell,T Curran,P J McKinnon,

The Sonic Hedgehog (SHH) signaling pathway is indispensable for development, and functions to activate a transcriptional program modulated by the GLI transcription factors. Here, we report that loss of a regulator of the SHH pathway, Suppressor of Fused (Sufu), resulted in early embryonic lethality in the mouse similar to inactivation of another SHH regulator, Patched1 (Ptch1). In contrast to Ptch1+/- mice, Sufu+/- mice were not tumor prone. However, in conjunction with p53 loss, Sufu+/- animals developed tumors including medulloblastoma and rhabdomyosarcoma. Tumors present in Sufu+/-p53-/- animals resulted from Sufu loss of heterozygosity. Sufu+/-p53-/- medulloblastomas also expressed a signature gene expression profile typical of aberrant SHH signaling, including upregulation of N-myc, Sfrp1, Ptch2 and cyclin D1. Finally, the Smoothened inhibitor, hedgehog antagonist, did not block growth of tumors arising from Sufu inactivation. These data demonstrate that Sufu is essential for development and functions as a tumor suppressor.

Loss of suppressor-of-fused function promotes tumorigenesis. Publishing Authors By Initials

Y Lee,R Kawagoe,K Sasai,Y Li,HR Russell,T Curran,PJ McKinnon,

For similar proteins: dna-binding proteins: tumor suppressor protein p53 research abstracts see: proteins: dna-binding proteins: tumor suppressor protein p53 research

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Loss of suppressor-of-fused function promotes tumorigenesis. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Oncogene

VOLUME: 26

Page Numbers: 6442-7

Journal Abbreviation: Oncogene

ISSN: 0950-9232

DAY: 23

MONTH: 04

YEAR: 2007

Loss of suppressor-of-fused function promotes tumorigenesis. Information

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LANGUAGE: eng

NlmUniqueID: 8711562

Loss of suppressor-of-fused function promotes tumorigenesis. Keywords Mesh Terms:

KEYWORDS: Tumor Suppressor Protein p53

MESH TERMS: physiology

Chemical & Substance for Abstract: Loss of suppressor-of-fused function promotes tumorigenesis. Information

Substance Name: patched receptors

Registry Number: 0

Grant and Affiliation Information for Loss of suppressor-of-fused function promotes tumorigenesis.

AFFILIATION: Department of Genetics and Tumor Cell Biology, St Jude Children's Research Hospital, Memphis, TN 38405, USA.

Country: England

AGENCY: United States NCI

GRANT: P30-CA21765

ACRONYM: CA

MEDLINETA: Oncogene

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