Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.

Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Research Abstract Details 

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Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Abstract Text:

The mechanisms by which ethanol induces changes in behavior are not well understood. Here, we show that Caenorhabditis elegans loss-of-function mutations in the synaptic vesicle-associated RAB-3 protein and its guanosine triphosphate exchange factor AEX-3 confer resistance to the acute locomotor effects of ethanol. Similarly, mice lacking one or both copies of Rab3A are resistant to the ataxic and sedative effects of ethanol, and Rab3A haploinsufficiency increases voluntary ethanol consumption. These data suggest a conserved role of RAB-3-/RAB3A-regulated neurotransmitter release in ethanol-related behaviors.

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Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Genes, brain, and behavior

VOLUME: 7

Page Numbers: 669-76

Journal Abbreviation: Genes Brain Behav.

ISSN: 1601-183X

DAY: 7

MONTH: 04

YEAR: 2008

Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Loss of RAB-3/A in Caenorhabditis elegans and the mouse affects behavioral response to ethanol.

AFFILIATION: The Ernest Gallo Clinic and Research Center, University of California at San Francisco, Emeryville, CA, USA.

Country: England

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MEDLINETA: Genes Brain Behav

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