Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease.

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Research Abstract Details 

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Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Abstract Text:

Grant Anderson,Ali Reza Noorian,Georgia Taylor,Mallappa Anitha,Doug Bernhard,Shanthi Srinivasan,James G Greene,Grant Anderson,Ali Reza Noorian,Georgia Taylor,Mallappa Anitha,Doug Bernhard,Shanthi Srinivasan,James G Greene,

Gastrointestinal (GI) dysfunction is the most common non-motor symptom of Parkinson's disease (PD). Symptoms of GI dysmotility include early satiety and nausea from delayed gastric emptying, bloating from poor small bowel coordination, and constipation and defecatory dysfunction from impaired colonic transit. Understanding the pathophysiology and treatment of these symptoms in PD patients has been hampered by the lack of investigation into GI symptoms and pathology in PD animal models. We report that the prototypical parkinsonian neurotoxin, MPTP (1-methyl 4-phenyl 1,2,3,6-tetrahydropyridine), is a selective dopamine neuron toxin in the enteric nervous system (ENS). When examined 10 days after treatment, there was a 40% reduction of dopamine neurons in the ENS of C57Bl/6 mice administered MPTP (60 mg/kg). There were no differences in the density of cholinergic or nitric oxide neurons. Electrophysiological recording of neural-mediated muscle contraction in isolated colon from MPTP-treated animals confirmed a relaxation defect associated with dopaminergic degeneration. Behaviorally, MPTP induced a transient increase in colon motility, but no changes in gastric emptying or small intestine transit. These results provide the first comprehensive assessment of gastrointestinal pathophysiology in an animal model of PD. They provide insight into the impact of dopaminergic dysfunction on gastrointestinal motility and a benchmark for assessment of other PD model systems.

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Publishing Authors By Initials

G Anderson,AR Noorian,G Taylor,M Anitha,D Bernhard,S Srinivasan,JG Greene,G Anderson,AR Noorian,G Taylor,M Anitha,D Bernhard,S Srinivasan,JG Greene,

For similar nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders: parkinson disease, secondary research abstracts see: nervous system diseases: central nervous system diseases: brain diseases: basal ganglia diseases: parkinsonian disorders: parkinson disease, secondary research

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Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Experimental neurology

VOLUME: 207

Page Numbers: 4-12

Journal Abbreviation: Exp. Neurol.

ISSN: 0014-4886

DAY: 18

MONTH: 05

YEAR: 2007

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370712

Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Keywords Mesh Terms:

KEYWORDS: Parkinson Disease, Secondary

MESH TERMS: physiopathology

Chemical & Substance for Abstract: Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease. Information

Substance Name: Dopamine

Registry Number: 51-61-6

Grant and Affiliation Information for Loss of enteric dopaminergic neurons and associated changes in colon motility in an MPTP mouse model of Parkinson's disease.

AFFILIATION: Department of Neurology, Emory University School of Medicine, Atlanta, GA 30322, USA.

Country: United States

AGENCY: United States NINDS

GRANT: K08 NS048858

ACRONYM: NS

MEDLINETA: Exp Neurol

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