Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Research Abstract Details 

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Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Abstract Text:

Lisa G Horvath,Susan M Henshall,James G Kench,Jennifer J Turner,David Golovsky,Phillip C Brenner,Gordon F O'Neill,Raji Kooner,Phillip D Stricker,John J Grygiel,Robert L Sutherland,

BACKGROUND: The role of the bone morphogenetic protein (BMP) pathway in prostate cancer (PC) is unclear. This study aimed to characterize aspects of the BMP pathway in PC by assessing BMP2, Smad8, and Smad4 expression in normal, hyperplastic, and malignant prostate tissue, and to correlate findings with progression to PC. METHODS: Radical prostatectomy (RP) specimens from 74 patients with clinically localized PC (median follow-up 51 months, range 15-152), 44 benign prostatic hypertrophy (BPH) lesions, and 4 normal prostates (NPs) were assessed for BMP2, Smad8, and Smad4 expression using immunohistochemistry. RESULTS: Both BMP2 (P < 0.001) and nuclear Smad4 (P < 0.0001) expression were significantly decreased in PC compared to benign prostate tissue. Nuclear Smad8 was present in normal/benign prostate tissue but absent in PC and adjacent hyperplasia. Furthermore, loss of BMP2 (P < 0.001) and decreased nuclear Smad4 (P = 0.05) expression correlated with increasing Gleason score. CONCLUSIONS: These data suggest that decreased BMP2, nuclear smad8 and nuclear Smad4 expression are associated with the progression to PC, and in particular loss of BMP2 and Smad4 are related to progression to a more aggressive phenotype.

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Publishing Authors By Initials

LG Horvath,SM Henshall,JG Kench,JJ Turner,D Golovsky,PC Brenner,GF O'Neill,R Kooner,PD Stricker,JJ Grygiel,RL Sutherland,

For similar peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: transforming growth factor beta research

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Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Prostate

VOLUME: 59

Page Numbers: 234-42

Journal Abbreviation: Prostate

ISSN: 0270-4137

DAY: 15

MONTH: May

YEAR: 2004

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8101368

Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Keywords Mesh Terms:

KEYWORDS: Transforming Growth Factor beta

MESH TERMS: biosynthesis

Chemical & Substance for Abstract: Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression. Information

Substance Name: bone morphogenetic protein 2

Registry Number: 0

Grant and Affiliation Information for Loss of BMP2, Smad8, and Smad4 expression in prostate cancer progression.

AFFILIATION: Cancer Research Program, Garvan Institute of Medical Research, St. Vincent's Hospital, Darlinghurst, Sydney, NSW, Australia.

Country: United States

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MEDLINETA: Prostate

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