Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Abstract Text:

Krzysztof Kobielak,Nicole Stokes,June de la Cruz,Lisa Polak,Elaine Fuchs,

During the hair cycle, follicle stem cells (SCs) residing in a specialized niche called the "bulge" undergo bouts of quiescence and activation to cyclically regenerate new hairs. Developmental studies have long implicated the canonical bone morphogenetic protein (BMP) pathway in hair follicle (HF) determination and differentiation, but how BMP signaling functions in the hair follicle SC niche remains unknown. Here, we use loss and gain of function studies to manipulate BMP signaling in the SC niche. We show that when the Bmpr1a gene is conditionally ablated, otherwise quiescent SCs are activated to proliferate, causing an expansion of the niche and loss of slow-cycling cells. Surprisingly, follicle SCs are not lost, however, but rather, they generate long-lived, tumor-like branches that express Sox4, Lhx2, and Sonic Hedgehog but fail to terminally differentiate to make hair. A key component of BMPR1A-deficient SCs is their elevated levels of both Lef1 and beta-catenin, which form a bipartite transcription complex required for initiation of the hair cycle. Although beta-catenin can be stabilized by Wnt signaling, we show that BMPR1A deficiency enhances beta-catenin stabilization in the niche through a pathway involving PTEN inhibition and PI3K/AKT activation. Conversely, sustained BMP signaling in the SC niche blocks activation and promotes premature hair follicle differentiation. Together, these studies reveal the importance of balancing BMP signaling in the SC niche.

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Publishing Authors By Initials

K Kobielak,N Stokes,J de la Cruz,L Polak,E Fuchs,

For similar proteins: armadillo domain proteins: beta catenin research abstracts see: proteins: armadillo domain proteins: beta catenin research

PUBMED ID PMID:

MEDLINE DATE:

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Proceedings of the National Academy of Sciences of

VOLUME: 104

Page Numbers: 10063-8

Journal Abbreviation: Proc. Natl. Acad. Sci. U.S.A.

ISSN: 0027-8424

DAY: 6

MONTH: 06

YEAR: 2007

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7505876

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Keywords Mesh Terms:

KEYWORDS: beta Catenin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling. Information

Substance Name: PTEN Phosphohydrolase

Registry Number: EC 3.1.3.67

Grant and Affiliation Information for Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.

AFFILIATION: Howard Hughes Medical Institute, Laboratory of Mammalian Cell Biology and Development, The Rockefeller University, 1230 York Avenue, New York, NY 10021, USA.

Country: United States

AGENCY: United States NIAMS

GRANT: R01 AR 050452

ACRONYM: AR

MEDLINETA: Proc Natl Acad Sci U S A

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling Related Publications

• 18q loss of heterozygosity in microsatellite stable colorectal cancer is correlated with CpG island methylator phenotype-negative (CIMP-0) and inversely with CIMP-low and CIMP-high.
• Acute myelopathy. Retrospective clinical, laboratory, MRI and outcome analysis of 49 cases.
• Adjuvant and neoadjuvant approaches in gastric cancer.
• Adverse events of blood-pressure-lowering drugs: evidence of high incidence in a clinical setting.
• Association of dietary patterns with cancer recurrence and survival in patients with stage III colon cancer.
• Calcium-pterin suppresses mitogen-induced tryptophan degradation and neopterin production in peripheral blood mononuclear cells.
• Canonical notch signaling functions as a commitment switch in the epidermal lineage.
• Cardiac tamponade: a life-threatening complication of Still's disease.
• Catenins: keeping cells from getting their signals crossed.
• Circulating insulin-like growth factor axis and the risk of pancreatic cancer in four prospective cohorts.
• Circulating insulin-like growth factor binding protein-1 and the risk of pancreatic cancer.
• Contribution of the frontal eye field to gaze shifts in the head-unrestrained monkey: effects of microstimulation.
• CpG island methylation, response to combination chemotherapy, and patient survival in advanced microsatellite stable colorectal carcinoma.
• Evaluation of markers for CpG island methylator phenotype (CIMP) in colorectal cancer by a large population-based sample.
• Fatty acid synthase overexpression in colorectal cancer is associated with microsatellite instability, independent of CpG island methylator phenotype.
• Focal adhesion kinase modulates tension signaling to control actin and focal adhesion dynamics.
• GABAA but not GABAB receptors in the rostral anterior cingulate cortex selectively modulate pain-induced escape/avoidance behavior.
• Hormone replacement therapy and survival after colorectal cancer diagnosis.
• Identification of novel genes in genomic islands that contribute to Salmonella typhimurium replication in macrophages.
• Long-term aspirin use and mortality in women.
• Loss of a quiescent niche but not follicle stem cells in the absence of bone morphogenetic protein signaling.
• Loss of nuclear p27 (CDKN1B/KIP1) in colorectal cancer is correlated with microsatellite instability and CIMP.
• Neurogenesis in the adult brain: is there an association with mental disorders?
• Oncogenic BRAF regulates beta-Trcp expression and NF-kappaB activity in human melanoma cells.
• Phase I study of gefitinib, irinotecan, 5-fluorouracil and leucovorin in patients with metastatic colorectal cancer.
• Plasma folate, vitamin B6, vitamin B12, and homocysteine and pancreatic cancer risk in four large cohorts.
• Ruthenium-catalyzed mild C-H oxyfunctionalization of cyclic steroidal ethers.
• Suicide attempt aborted by an implantable defibrillator.
• Tcf3 governs stem cell features and represses cell fate determination in skin.
• The relationship between basal level of anxiety and the affective response to inflammation.