Longitudinal study of physiologic insulin resistance and metabolic changes of puberty.

Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Research Abstract Details 

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Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Abstract Text:

Tamara S Hannon,Janine Janosky,Silva A Arslanian,

Cross-sectional studies have shown that 1) adolescents are insulin resistant compared with prepubertal children and adults, 2) pubertal insulin resistance is likely mediated by growth hormone (GH), and 3) pubertal insulin resistance is associated with increased fat oxidation and decreased glucose oxidation. The aim of this study was to assess the validity of these cross-sectional observations by performing a longitudinal study in normal children during the prepubertal and pubertal periods. Nine healthy, normal weight, prepubertal children underwent hyperinsulinemic-euglycemic and hyperglycemic clamp studies for evaluation of insulin sensitivity and insulin secretion. Children had repeat evaluations during puberty. Consistent with cross-sectional observations, this longitudinal study demonstrated that during puberty: 1) insulin sensitivity decreased by approximately 50%, 2) the decrease in insulin sensitivity was compensated by a doubling in insulin secretion, and 3) the decrease in insulin sensitivity was independent of changes in percentage of body fat. Puberty was associated with increased total body lipolysis and decreased glucose oxidation. A novel observation is the demonstration of approximately 50% decrease in adiponectin levels at the pubertal time point. These metabolic changes are proposed to be partially mediated by increased GH secretion and are consistent with the Randle cycle of competition between glucose and fat oxidation.

Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Publishing Authors By Initials

TS Hannon,J Janosky,SA Arslanian,

For similar reproductive and urinary physiology: reproduction: sexual development: puberty research abstracts see: reproductive and urinary physiology: reproduction: sexual development: puberty research

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Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Pediatric research

VOLUME: 60

Page Numbers: 759-63

Journal Abbreviation: Pediatr. Res.

ISSN: 0031-3998

DAY: 25

MONTH: 10

YEAR: 2006

Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Information

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LANGUAGE: eng

NlmUniqueID: 100714

Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Keywords Mesh Terms:

KEYWORDS: Puberty

MESH TERMS: physiology

Chemical & Substance for Abstract: Longitudinal study of physiologic insulin resistance and metabolic changes of puberty. Information

Substance Name: Growth Hormone

Registry Number: 9002-72-6

Grant and Affiliation Information for Longitudinal study of physiologic insulin resistance and metabolic changes of puberty.

AFFILIATION: Division of Pediatric Endocrinology, Metabolism, and Diabetes Mellitus and Division of Weight Management and Wellness, Children's Hospital of Pittsburgh, Pittsburgh, Pennsylvania 15213, USA. tamara.hannon@chp.edu

Country: United States

AGENCY: United States NICHD

GRANT: R01 HD27503

ACRONYM: HD

MEDLINETA: Pediatr Res

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