Longitudinal MRI and cognitive change in healthy elderly.

Longitudinal MRI and cognitive change in healthy elderly. Research Abstract Details 

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Longitudinal MRI and cognitive change in healthy elderly. Abstract Text:

Joel H Kramer,Dan Mungas,Bruce R Reed,Margaret E Wetzel,Molly M Burnett,Bruce L Miller,Michael W Weiner,Helena C Chui,

Cross-sectional studies of normal aging indicate an association between memory and hippocampal volume, and between executive functioning and subcortical-frontal circuits. Much less is known, however, about the relationship between longitudinal MRI changes and cognitive decline. The authors hypothesized that longitudinal change in memory would be best predicted by change in hippocampal volumes, whereas change in executive functioning would be best predicted by cortical atrophy and progression of MRI markers of cerebrovascular disease. For this study, 50 healthy elderly subjects underwent structural MRI and cognitive testing at baseline and again at follow-up, with a mean follow-up interval of 45 months. Volumetric MRI measures were hippocampus, cortical gray matter, white matter signal hyperintensity (WMSH), and lacunae. Neuropsychological measures were psychometrically robust composite scores of episodic memory (MEM) and executive functioning (EXEC). Hierarchical multiple regression indicated that a decrease in hippocampus was associated with a decline in MEM, whereas decreased cortical gray matter and increased WMSH were independently associated with a decline in EXEC. Results suggest that in normal aging, cognitive functioning declines as cortical gray matter and hippocampus decrease, and WMSH increases. The association between WMSH and EXEC further highlights the cognitive sequealae associated with cerebrovascular disease in normal elderly.

Longitudinal MRI and cognitive change in healthy elderly. Publishing Authors By Initials

JH Kramer,D Mungas,BR Reed,ME Wetzel,MM Burnett,BL Miller,MW Weiner,HC Chui,

For similar psychological phenomena and processes: psychomotor performance research abstracts see: psychological phenomena and processes: psychomotor performance research

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Longitudinal MRI and cognitive change in healthy elderly. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neuropsychology

VOLUME: 21

Page Numbers: 412-8

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ISSN: 0894-4105

DAY: 3

MONTH: Jul

YEAR: 2007

Longitudinal MRI and cognitive change in healthy elderly. Information

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LANGUAGE: eng

NlmUniqueID: 8904467

Longitudinal MRI and cognitive change in healthy elderly. Keywords Mesh Terms:

KEYWORDS: Psychomotor Performance

MESH TERMS: physiology

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Grant and Affiliation Information for Longitudinal MRI and cognitive change in healthy elderly.

AFFILIATION: Department of Neurology, San Francisco Medical Center, University of California, San Francisco, CA 94143, USA. jkramer@memory.ucsf.edu

Country: United States

AGENCY: United States NIA

GRANT: AG22983

ACRONYM: AG

MEDLINETA: Neuropsychology

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