Longitudinal ECG changes in cocaine users during extended abstinence.

Longitudinal ECG changes in cocaine users during extended abstinence. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Longitudinal ECG changes in cocaine users during extended abstinence. Abstract Text:

BACKGROUND: Cocaine lengthens electrocardiographic QTc, QRS and PR intervals through blockade of sodium and potassium channels, but changes during withdrawal have not been well studied. METHODS: We recorded weekly electrocardiograms (ECGs) from 25 physically healthy cocaine users (84.0% men, mean [S.D.] age 34.7 [4.1] years, 9.0 [5.2] years of cocaine use, 9.4 [3.5] days of use in the 2 weeks prior to admission) over 3 months of monitored abstinence on a closed ward. Subjects had minimal current use of other drugs. Baseline ECGs were recorded 20.5h [16.6] after last cocaine use. RESULTS: Baseline QTc interval correlated positively with total amount of cocaine used and amount used per day in the 2 weeks prior to ward admission. There was a significant 10.5ms [12.9] shortening of QTc interval during the first week of withdrawal, with no further significant changes thereafter. There were no significant changes in PR or QRS intervals. CONCLUSIONS: These findings suggest that cocaine-associated QTc prolongation returns toward normal during the first week of cocaine abstinence.

Longitudinal ECG changes in cocaine users during extended abstinence. Publishing Authors By Initials

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Longitudinal ECG changes in cocaine users during extended abstinence. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Drug and alcohol dependence

VOLUME: 95

Page Numbers: 160-3

Journal Abbreviation:

ISSN: 0376-8716

DAY: 1

MONTH: 02

YEAR: 2008

Longitudinal ECG changes in cocaine users during extended abstinence. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 7513587

Longitudinal ECG changes in cocaine users during extended abstinence. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Longitudinal ECG changes in cocaine users during extended abstinence. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Longitudinal ECG changes in cocaine users during extended abstinence.

AFFILIATION: Intramural Research Program, National Institute on Drug Abuse, National Institutes of Health, 5500 Nathan Shock Drive, Baltimore, MD 21224, USA.

Country: Ireland

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Drug Alcohol Depend

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Longitudinal ECG changes in cocaine users during extended abstinence Related Publications

• Chapter 63 The future of stroke prevention by risk factor modification.
• Derivation of the DIVA Score: A Clinical Prediction Rule for the Identification of Children With Difficult Intravenous Access.
• Development and physiological regulation of intestinal lipid absorption. II. Dietary lipid absorption, complex lipid synthesis, and the intracellular packaging and secretion of chylomicrons.
• Development of a German version of the knee outcome survey for daily activities.
• Diagnosis and management of vascular cognitive impairment.
• Efficiency of human immunodeficiency virus type 1 postentry infection processes: evidence against disproportionate numbers of defective virions.
• Exercise stress testing in recently abstinent chronic cocaine abusers.
• Gray matter atrophy in patients with ischemic stroke with cognitive impairment.
• HIV-1 inactivation by 4-vinylpyridine is enhanced by dissociating Zn(2+) from nucleocapsid protein.
• Hypoglycemic hemiplegia: Insulinoma masquerading as stroke.
• Life after ESPRIT: which first-line antiplatelet treatment should we use?
• Lipoprotein-associated phospholipase A2 and risk of stroke.
• Longitudinal ECG changes in cocaine users during extended abstinence.
• Longitudinal changes in white matter following ischemic stroke: a three-year follow-up study.
• Nucleocapsid protein function in early infection processes.
• Pathophysiological effects of cocaine in humans: review of scientific issues.
• Pediatric emergency department visits for diarrheal illness increased after release of undertreated sewage.
• Physiological and physiopathological effects of cocaine.
• Primary prevention of stroke: impact of healthy lifestyle.
• Processes controlling the thermal regime of saltmarsh channel beds.
• Quality of primary care and subsequent pediatric emergency department utilization.
• Racial differences in ischemic cerebrovascular disease.
• Regarding "Buprenorphine reduces alcohol drinking through activation of the nociceptin/orphanin FQ-NOP receptor system".
• Risk of psychoactive substance dependence among substance users in a trauma inpatient population.
• Screening for poor short-term outcome in acute pediatric asthma.
• Single and multiple doses of rimonabant antagonize acute effects of smoked cannabis in male cannabis users.
• Sociodemographic characteristics associated with substance use status in a trauma inpatient population.
• Species richness and the analytic geometry of latitudinal and altitudinal gradients.
• The novel protein kinase C isoforms -{delta} and -{varepsilon} modulate caerulein-induced zymogen activation in pancreatic acinar cells.
• Update on the management of hypertension to prevent stroke.