Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Research Abstract Details 

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Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Abstract Text:

Kejal Kantarci,Stephen D Weigand,Ronald C Petersen,Bradley F Boeve,David S Knopman,Jeffrey Gunter,Denise Reyes,Maria Shiung,Peter C O'Brien,Glenn E Smith,Robert J Ivnik,Eric G Tangalos,Clifford R Jack,

Magnetic resonance (MR)-based volume measurements of atrophy are potential markers of disease progression in patients with amnestic mild cognitive impairment (MCI) and Alzheimer's disease (AD). Longitudinal changes in (1)H MR spectroscopy ((1)H MRS) metabolite markers have not been characterized in MCI subjects. Our objective was to determine the longitudinal (1)H MRS metabolite changes in patients with MCI, and AD, and to compare (1)H MRS metabolite ratios and ventricular volumes in tracking clinical disease progression in AD. The neuronal integrity marker N-acetylaspartate/creatine ratio declined in MCI and AD patients compared to cognitively normal elderly. The change in (1)H MRS metabolite ratios correlated with clinical progression about as strongly as the rate of ventricular expansion, suggesting that (1)H MRS metabolite ratios may be useful markers for the progression of AD. Choline/creatine ratio declined in stable MCI, compared to converter MCI patients and cognitively normal elderly, which may be related to a compensatory mechanism in MCI patients who did not to progress to AD.

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Publishing Authors By Initials

K Kantarci,SD Weigand,RC Petersen,BF Boeve,DS Knopman,J Gunter,D Reyes,M Shiung,PC O'Brien,GE Smith,RJ Ivnik,EG Tangalos,CR Jack,

For similar investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research abstracts see: investigative techniques: epidemiologic methods: epidemiologic study characteristics as topic: epidemiologic studies: case-control studies: retrospective studies research

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Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 1330-9

Journal Abbreviation: Neurobiol. Aging

ISSN: 1558-1497

DAY: 24

MONTH: 07

YEAR: 2006

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100437

Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Keywords Mesh Terms:

KEYWORDS: Retrospective Studies

MESH TERMS: metabolism

Chemical & Substance for Abstract: Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease. Information

Substance Name: N-acetylaspartate

Registry Number: 997-55-7

Grant and Affiliation Information for Longitudinal 1H MRS changes in mild cognitive impairment and Alzheimer's disease.

AFFILIATION: Department of Radiology, Mayo Clinic, 200 First Street SW, Rochester, MN 55905, USA. kantarci.kejal@mayo.edu <kantarci.kejal@mayo.edu>

Country: United States

AGENCY: United States NICHD

GRANT: K12-HD049078

ACRONYM: HD

MEDLINETA: Neurobiol Aging

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