Longevity and correlated frailty in multigenerational families.

Longevity and correlated frailty in multigenerational families. Research Abstract Details 

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Longevity and correlated frailty in multigenerational families. Abstract Text:

Gilda Garibotti,Ken R Smith,Richard A Kerber,Kenneth M Boucher,

Multigenerational pedigrees provide an opportunity for assessing the effects of unobserved environmental and genetic effects on longevity (i.e., frailty). This article applies Cox proportional hazards models to data from three-generation pedigrees in the Utah Population Database using two different frailty specification schemes that account for common environments (shared frailty) and genetic effects (correlated frailty). In a model that includes measures of familial history of longevity and both frailty effects, we find that the variance component due to genetic factors is comparable to the one attributable to shared environments: Standard deviations of the correlated and the shared frailty distributions are 0.143 and 0.186, respectively. Through simulations, we also show a greater reduction in the bias of parameter estimates for fixed covariates through the use of the correlated frailty model.

Longevity and correlated frailty in multigenerational families. Publishing Authors By Initials

G Garibotti,KR Smith,RA Kerber,KM Boucher,

For similar investigative techniques: epidemiologic methods: statistics as topic: models, statistical: proportional hazards models research abstracts see: investigative techniques: epidemiologic methods: statistics as topic: models, statistical: proportional hazards models research

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Longevity and correlated frailty in multigenerational families. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The journals of gerontology. Series A, Biological

VOLUME: 61

Page Numbers: 1253-61

Journal Abbreviation: J. Gerontol. A Biol. Sci. Med.

ISSN: 1079-5006

DAY: 3

MONTH: Dec

YEAR: 2006

Longevity and correlated frailty in multigenerational families. Information

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LANGUAGE: eng

NlmUniqueID: 9502837

Longevity and correlated frailty in multigenerational families. Keywords Mesh Terms:

KEYWORDS: Proportional Hazards Models

MESH TERMS: genetics

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Grant and Affiliation Information for Longevity and correlated frailty in multigenerational families.

AFFILIATION: Huntsman Cancer Institute, University of Utah, Salt Lake City, Utah 84112, USA.

Country: United States

AGENCY: United States NIA

GRANT: AG022095

ACRONYM: AG

MEDLINETA: J Gerontol A Biol Sci Med Sci

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