Long-term treatment with diazoxide in childhood hyperinsulinism.

Long-term treatment with diazoxide in childhood hyperinsulinism. Research Abstract Details 

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Long-term treatment with diazoxide in childhood hyperinsulinism. Abstract Text:

D B Grant,D B Dunger,E C Burns,

This paper reviews the outcome in 12 children with hyperinsulinaemic hypoglycaemia who first developed symptoms between the ages of 2 and 8 months and who were treated with diazoxide (5-20 mg/kg/day) for 2-13 years. Two cases required subtotal pancreatectomy at the ages of 5 and 10 years because of recurrent hypoglycaemia and one girl with severe retardation died at the age of 6 years while still on diazoxide therapy. Two patients aged 3.5 and 9 years are still on treatment and in 7 cases diazoxide was discontinued between the ages of 2.5 and 14 years, indicating that spontaneous remission can be expected in a high proportion of children with post-neonatal hyperinsulinaemic hypoglycaemia. Of the 9 children who started diazoxide within 3 months of the onset of symptoms, 5 are of normal intelligence and 4 are moderately retarded (IQs 63-71). In 3 children diazoxide was started 8 months to 3 years after the onset of symptoms; two are retarded (IQs 60-70) and the third was severely retarded and died aged 6 years.

Long-term treatment with diazoxide in childhood hyperinsulinism. Publishing Authors By Initials

DB Grant,DB Dunger,EC Burns,

For similar digestive system diseases: pancreatic diseases research abstracts see: digestive system diseases: pancreatic diseases research

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Long-term treatment with diazoxide in childhood hyperinsulinism. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta endocrinologica. Supplementum

VOLUME: 279

Page Numbers: 340-5

Journal Abbreviation:

ISSN: 0300-9750

DAY: 12

MONTH: 02

YEAR: 1986

Long-term treatment with diazoxide in childhood hyperinsulinism. Information

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LANGUAGE: eng

NlmUniqueID: 370313

Long-term treatment with diazoxide in childhood hyperinsulinism. Keywords Mesh Terms:

KEYWORDS: Pancreatic Diseases

MESH TERMS: therapy

Chemical & Substance for Abstract: Long-term treatment with diazoxide in childhood hyperinsulinism. Information

Substance Name: Diazoxide

Registry Number: 364-98-7

Grant and Affiliation Information for Long-term treatment with diazoxide in childhood hyperinsulinism.

AFFILIATION:

Country: DENMARK

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MEDLINETA: Acta Endocrinol Suppl (Copenh)

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