Long-term survival and risk of second cancers after radiotherapy for cervical cancer.

Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Research Abstract Details 

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Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Abstract Text:

Tatsuya Ohno,Shingo Kato,Shinichiro Sato,Kenjiro Fukuhisa,Takashi Nakano,Hirohiko Tsujii,Tatsuo Arai,

PURPOSE: To evaluate the risk of second cancers after cervical cancer treated with radiotherapy for Asian populations. METHODS AND MATERIALS: We reviewed 2,167 patients with cervical cancer undergoing radiotherapy between 1961 and 1986. Intracavitary brachytherapy was performed with high-dose rate source (82%) or low-dose rate source (12%). Relative risk (RR), absolute excess risk (AR), and cumulative risk of second cancer were calculated using the Japanese disease expectancy table. For 1,031 patients, the impact of smoking habit on the increasing risk of second cancer was also evaluated. RESULTS: The total number of person-years of follow-up was 25,771, with 60 patients being lost to follow-up. Among the 2,167 patients, 1,063 (49%) survived more than 10 years. Second cancers were observed in 210 patients, representing a significant 1.2-fold risk (95% confidence interval [CI], 1.1-1.4) of developing second cancer compared with the general population, 1.6% excess risk per person per decade of follow-up, and elevating cumulative risk up to 23.8% (95% CI, 20.3-27.3) at 30 years after radiotherapy. The RR of second cancer was 1.6-fold for patients with the smoking habit and 1.4-fold for those without. CONCLUSIONS: Small but significant increased risk of second cancer was observed among Japanese women with cervical cancer mainly treated with high-dose rate brachytherapy. Considering the fact that about half of the patients survived more than 10 years, the benefit of radiotherapy outweighs the risk of developing second cancer.

Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Publishing Authors By Initials

T Ohno,S Kato,S Sato,K Fukuhisa,T Nakano,H Tsujii,T Arai,

For similar neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research abstracts see: neoplasms: neoplasms by site: urogenital neoplasms: genital neoplasms, female: uterine neoplasms: uterine cervical neoplasms research

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Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: International journal of radiation oncology, biolo

VOLUME: 69

Page Numbers: 740-5

Journal Abbreviation: Int. J. Radiat. Oncol. Biol. P

ISSN: 0360-3016

DAY: 1

MONTH: Nov

YEAR: 2007

Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Information

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LANGUAGE: eng

NlmUniqueID: 7603616

Long-term survival and risk of second cancers after radiotherapy for cervical cancer. Keywords Mesh Terms:

KEYWORDS: Uterine Cervical Neoplasms

MESH TERMS: radiotherapy

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Grant and Affiliation Information for Long-term survival and risk of second cancers after radiotherapy for cervical cancer.

AFFILIATION: Research Center for Charged Particle Therapy, National Institute of Radiological Sciences, Chiba, Japan. t_ohno@nirs.go.jp

Country: United States

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MEDLINETA: Int J Radiat Oncol Biol Phys

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