Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors.

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Abstract Text:

Erin E Gray,Ann E Fink,Joshua ,Bryce Vissel,Thomas J O'dell,Erin E Gray,Ann E Fink,Joshua ,Bryce Vissel,Thomas J O'dell,Erin E Gray,Ann E Fink,Joshua ,Bryce Vissel,Thomas J O'Dell,Erin E Gray,Ann E Fink,Joshua ,Bryce Vissel,Thomas J O'Dell,

Activity-dependent insertion of AMPA-type glutamate receptors is thought to underlie long-term potentiation (LTP) at Schaffer collateral fiber synapses on pyramidal cells in the hippocampal CA1 region. Although it is widely accepted that the AMPA receptors at these synapses contain glutamate receptor type 2 (GluR2) subunits, recent findings suggest that LTP in hippocampal slices obtained from 2- to 3-wk-old rodents is dependent on the transient postsynaptic insertion and activation of Ca(2+)-permeable, GluR2-lacking AMPA receptors. Here we examined whether LTP in slices prepared from adult animals exhibits similar properties. In contrast to previously reported findings, pausing synaptic stimulation for as long as 30 min post LTP induction had no effect on LTP maintenance in slices from 2- to 3-mo-old mice. LTP was also not disrupted by postinduction application of a selective blocker of GluR2-lacking AMPA receptors or the broad-spectrum glutamate receptor antagonist kynurenate. Although these results suggest that the role of GluR2-lacking AMPA receptors in LTP might be regulated during postnatal development, LTP in slices obtained from 15- to 21-day-old mice also did not require postinduction synaptic stimulation or activation of GluR2-lacking AMPA receptors. Thus the insertion and activation of GluR2-lacking AMPA receptors do not appear to be fundamental processes involved in LTP at excitatory synapses in the hippocampal CA1 region.

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Publishing Authors By Initials

EE Gray,AE Fink,J ,B Vissel,TJ O'dell,EE Gray,AE Fink,J ,B Vissel,TJ O'dell,EE Gray,AE Fink,J ,B Vissel,TJ O'Dell,EE Gray,AE Fink,J ,B Vissel,TJ O'Dell,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Journal of neurophysiology

VOLUME: 98

Page Numbers: 2488-92

Journal Abbreviation: J. Neurophysiol.

ISSN: 0022-3077

DAY: 25

MONTH: 07

YEAR: 2007

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375404

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors.

AFFILIATION: Department of Physiology, David Geffen School of Medicine at UCLA, 53-231 Center for the Health Sciences, Box 951751, Los Angeles, CA 90095-1751. todell@mednet.ucla.edu).

Country: United States

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: J Neurophysiol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors Related Publications

• 2009 AHA environmental scan.
• AHA Environmental Assessment 2008.
• Adiponectin gene ADIPOQ SNP associations with serum adiponectin in two female populations and effects of SNPs on promoter activity.
• Age-dependent modulation of hippocampal long-term potentiation by antioxidant enzymes.
• Association of Common JAK2 Variants With Body Fat, Insulin Sensitivity and Lipid Profile.
• Central nervous system depressant effects of some indolylethylpyridines.
• Emergence of ideal membrane cascades for downstream processing.
• Evidence That MR Diffusion Tensor Imaging (Tractography) Predicts the Natural History of Regional Progression in Patients Irradiated Conformally for Primary Brain Tumors.
• Genes mediating sex-specific behaviors in Drosophila.
• How to protect accounts receivables from medical partner and employee lawsuits.
• Influence of anesthesia on the neuromuscular blocking activity of mylaxen.
• It is the best of times; it is the worst of times: Is there a way forward? A plethora of treatment options for rheumatoid arthritis, but critical trial design issues.
• Long-Term Potentiation in the Hippocampal CA1 Region Does Not Require Insertion and Activation of GluR2-Lacking AMPA Receptors.
• Methamphetamine-induced neural and cognitive changes in rodents.
• Newer treatments for age-related macular degeneration.
• SHP-2 and PI3-kinase genes PTPN11 and PIK3R1 may influence serum apoB and LDL cholesterol levels in normal women.
• Studies on the amoeboid and flagellate stages of Naegleria.
• TUB is a candidate gene for late-onset obesity in women.
• The Dominant Cold-Sensitive Out-Cold Mutants of Drosophila melanogaster Have Novel Missense Mutations in the Voltage-Gated Sodium Channel Gene paralytic.
• Tips on selling your medical practice.
• Traumatic rupture of the membranous urethra.