Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma.

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Abstract Text:

J Sakata,Y Shirai,T Wakai,K Kaneko,K Hatakeyama,

AIMS: Intrahepatic recurrence is the most common manifestation of failure after local ablation therapy for hepatocellular carcinoma. The present study evaluates the safety and efficacy of partial hepatectomy for intrahepatic recurrence after prior local ablation. METHODS: A retrospective analysis was conducted of 188 consecutive patients with hepatocellular carcinoma who underwent either partial hepatectomy for recurrence after prior local ablation (n=13) or partial hepatectomy as initial local treatment (n=175). The 13 patients with recurrence after prior local ablation were referred to our division after the resectable recurrences were considered to be resistant to non-surgical treatment modalities. RESULTS: The incidences of postoperative morbidity and mortality were similar for patients with prior local ablation and patients without prior local ablation (p=0.75 and p=0.52, respectively). The overall survival rates after hepatectomy were comparable between patients with prior local ablation (median survival time of 86months; cumulative 5-year survival rate of 63%) and patients without prior local ablation (median survival time of 76months; cumulative 5-year survival rate of 54%; p=0.60). The disease-free survival rates after hepatectomy were significantly worse for patients with prior local ablation based on both univariate (p=0.01) and multivariate (relative risk, 2.73; p<0.01) analyses. CONCLUSIONS: Hepatectomy can be performed safely and may be efficacious, in terms of overall survival, for selected patients with intrahepatic recurrence after prior local ablation for hepatocellular carcinoma. On the other hand, prior local ablation appears to increase the probability of failure after hepatectomy.

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Publishing Authors By Initials

J Sakata,Y Shirai,T Wakai,K Kaneko,K Hatakeyama,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of surgical oncology : the journa

VOLUME: 34

Page Numbers: 433-8

Journal Abbreviation: Eur J Surg Oncol

ISSN: 1532-2157

DAY: 1

MONTH: 05

YEAR: 2007

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8504356

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma.

AFFILIATION: Division of Digestive and General Surgery, Niigata University Graduate School of Medical and Dental Sciences, 1-757 Asahimachi-dori, Niigata City 951-8510, Japan.

Country: England

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Eur J Surg Oncol

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma Related Publications

• A highly stereocontrolled total synthesis of dysiherbaine.
• Anti-tumor activity of ESX1 on cancer cells harboring oncogenic K-ras mutation.
• Asymmetric total synthesis of (+)-phoslactomycin B.
• Azafullerene encapsulated single-walled carbon nanotubes with n-type electrical transport property.
• Characterization of functional domains of the hemolytic lectin CEL-III from the marine invertebrate Cucumaria echinata.
• Characterization of the {alpha}-Helix Region in Domain 3 of the Haemolytic Lectin CEL-III: Implications for Self-Oligomerization and Haemolytic Processes.
• Clinicopathologic characteristics of clinically relevant cytomegalovirus infection in inflammatory bowel disease.
• Combined major hepatectomy and pancreaticoduodenectomy for locally advanced biliary carcinoma: long-term results.
• Deregulation of beta-catenin signal by Helicobacter pylori CagA requires the CagA-multimerization sequence.
• Experimental allergic orchitis in mice. Histopathological and Immunological studies.
• Extranodal spreading of esophageal squamous cell carcinoma: clinicopathological characteristics and prognostic impact.
• Function approximation approach to the inference of reduced NGnet models of genetic networks.
• Group g streptococcal bacteremia and vertebral osteomyelitis in a homosexual man with amebic colitis.
• Helicobacter pylori CagA interacts with E-cadherin and deregulates the beta-catenin signal that promotes intestinal transdifferentiation in gastric epithelial cells.
• Integrative genome-wide expression analysis bears evidence of estrogen receptor-independent transcription in heregulin-stimulated mcf-7 cells.
• Intrahepatic lymphatic invasion independently predicts poor survival and recurrences after hepatectomy in patients with colorectal carcinoma liver metastases.
• Long-term outcomes after hepatectomy for recurrences after prior local ablation for hepatocellular carcinoma.
• Mucin expression, p53 overexpression, and peritumoral lymphocytic infiltration of advanced colorectal carcinoma with mucus component: Is mucinous carcinoma a distinct histological entity?
• Perimuscular connective tissue contains more and larger lymphatic vessels than the shallower layers in human gallbladders.
• Preparation and characterization of polyurethane foams using a palm oil-based polyol.
• Purification of an active gelatinase from collagen fiber fraction of granulation tissue in rats.
• Repair of traumatic tricuspid regurgitation by bicuspidization.
• SagA of CagA in Helicobacter pylori pathogenesis.
• Surgical management of petrous apex cholesteatoma: a therapeutic scheme.
• TRIM68 regulates ligand-dependent transcription of androgen receptor in prostate cancer cells.
• Topological analysis of MAPK cascade for kinetic ErbB signaling.
• Transgenic expression of Helicobacter pylori CagA induces gastrointestinal and hematopoietic neoplasms in mouse.
• Ubiquitylation of epsilon-COP by PIRH2 and regulation of the secretion of PSA.
• Wall shear stress and intrahepatic leukocytes of graft in living related donor liver transplantation.
• [Irinotecan Plus Gemcitabine(IRINOGEM)in the Treatment of Biliary Malignancies.]