Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy.

Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy. Research Abstract Details 

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Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy. Abstract Text:

BACKGROUND: Diabetes mellitus is an independent risk factor for increased morbidity and mortality in heart failure (HF) patients. AIMS: To compare functional and structural improvement, as well as long-term outcome, between diabetic and non-diabetic HF patients treated with cardiac resynchronization therapy (CRT). METHODS: We compared response to CRT in 141 diabetic and 214 non-diabetic consecutive patients. Major events were; death from any cause, urgent heart transplantation and implantation of a left ventricular (LV) assist device. Frequencies of hospitalisation and defibrillator (CRT-D) discharges were also analyzed. RESULTS: CRT was able to significantly improve functional capacity, ventricular geometry and neurohumoral imbalance in both diabetic and non-diabetic patients over a median follow-up time of 34 months. Overall event-free survival was similar in diabetic and non-diabetic patients (HR 1.23, p=0.363), as was survival free from CRT-D interventions (HR 1.72; p=0.115) and hospitalisations (HR 1.12; p=0.500). On multivariable analysis, NYHA class IV (p=0.002), low LV ejection fraction (p=0.002), absence of beta-blocker therapy (p<0.001), impaired renal function (p=0.003), presence of an epicardial lead (p=0.025), but not diabetes (p=0.821) were associated with a poor outcome after CRT. CONCLUSIONS: Diabetic HF patients treated with CRT had a very favourable functional and survival outcome, which was comparable to non-diabetic patients.

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Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: European journal of heart failure : journal of the

VOLUME: 10

Page Numbers: 298-307

Journal Abbreviation: Eur. J. Heart Fail.

ISSN: 1388-9842

DAY: 4

MONTH: 03

YEAR: 2008

Long-term outcome in diabetic heart failure patients treated with cardiac resynchronization therapy. Information

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LANGUAGE: eng

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AFFILIATION: Division of Cardiology, University Hospital, Magdeburg, Germany; Department of Cardiovascular Sciences, University of Insubria, Varese, Italy; Cardiovascular Interventional Radiology Department, IRCCS Policlinico San Donato, San Donato Milanese, Italy.

Country: Netherlands

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MEDLINETA: Eur J Heart Fail

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