Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study.

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Abstract Text:

Shoji Sanada,Hiroshi Asanuma,Yukihiro Koretsune,Kouki Watanabe,Shinsuke Nanto,Nobuhisa Awata,Noritake Hoki,Masatake Fukunami,Masafumi Kitakaze,Masatsugu Hori,Shoji Sanada,Hiroshi Asanuma,Yukihiro Koretsune,Kouki Watanabe,Shinsuke Nanto,Nobuhisa Awata,Noritake Hoki,Masatake Fukunami,Masafumi Kitakaze,Masatsugu Hori,

Adenosine is known as an endogenous cardioprotectant. We previously reported that plasma adenosine levels increase in patients with chronic heart failure (CHF), and that a treatment that further elevates plasma adenosine levels may improve the pathophysiology of CHF. Therefore, we performed a prospective, open-randomized clinical trial to determine whether or not exposure to dipyridamole for 1 year improves CHF pathophysiology compared with conventional treatments. The study enrolled 28 patients (mean+/-SEM: 66+/-4 years of age) attending specialized CHF outpatient clinics with New York Heart Association (NYHA) class II or III, no major complications, and stable CHF status during the most recent 6 months under fixed medications. They were randomized into three groups with or without dipyridamole (Control: n=9; 75 mg/day: n=9; 300 mg/day: n=10) in addition to their original medications and were followed up for 1 year. The other drugs were not altered. Among the enrolled patients, 100%, 4%, 100%, and 79% received angiotensin-converting enzyme inhibitors, aldosterone analogue, loop diuretics, and beta-adrenoceptor blocker, respectively. Fifteen patients suffered from dilated cardiomyopathy, and 7/3/3 patients suffered from ischemic/valvular/hypertensive heart diseases, respectively. Mean blood pressure was comparable among the groups. While the baseline conditions were comparable, we found that echocardiographic ejection fraction (p<0.01 vs. baseline, p<0.01 vs. Control), left ventricular systolic diameter (p<0.05, p<0.05), Specific Activity Scale (SAS) score (p<0.05, p<0.01), maximal oxygen consumption (p<0.05, p<0.05) and plasma B-type natriuretic peptide level (p<0.01, p<0.01) were significantly improved in patients with dipyridamole after 1 year, generally in a dose-dependent manner. Therefore, we suggest that an additional administration of dipyridamole further improves CHF pathophysiology.

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Publishing Authors By Initials

S Sanada,H Asanuma,Y Koretsune,K Watanabe,S Nanto,N Awata,N Hoki,M Fukunami,M Kitakaze,M Hori,S Sanada,H Asanuma,Y Koretsune,K Watanabe,S Nanto,N Awata,N Hoki,M Fukunami,M Kitakaze,M Hori,

For similar abstracts research abstracts see: abstracts research

PUBMED ID PMID:

MEDLINE DATE:

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Hypertension research : official journal of the Ja

VOLUME: 30

Page Numbers: 913-9

Journal Abbreviation: Hypertens. Res.

ISSN: 0916-9636

DAY: 30

MONTH: Oct

YEAR: 2007

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 9307690

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Keywords Mesh Terms:

KEYWORDS:

MESH TERMS:

Chemical & Substance for Abstract: Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study. Information

Substance Name:

Registry Number:

Grant and Affiliation Information for Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study.

AFFILIATION: Department of Cardiovascular Medicine, Osaka University Graduate School of Medicine, Suita, Japan.

Country: Japan

AGENCY:

GRANT:

ACRONYM:

MEDLINETA: Hypertens Res

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study Related Publications

• A dibenzoylmethane derivative protects dopaminergic neurons against both oxidative stress and endoplasmic reticulum stress.
• A smart video magnifier controlled by the visibility signal of a low vision user.
• Adrenodoxin-cytochrome P450scc interaction as revealed by EPR spectroscopy: comparison with the putidaredoxin-cytochrome P450cam system.
• Compact synchrotron light source of the HSRC.
• Determination of nonylphenol ethoxylates and octylphenol ethoxylates in environmental samples using 13C-labeled surrogate compounds.
• Differences in substrate selectivities of the SPOUT superfamily of methyltransferases.
• Drug-resistance gene expression and progression of astrocytic tumors.
• Effect of combined humanPTH(1-34) and calcitonin treatment in ovariectomized rats.
• Effect of intracoronary thrombectomy on 30-day mortality in patients with acute myocardial infarction.
• Effect of molecular chirality and side chain bulkiness on angiogenesis of haloacetylcarbamoyl-2-nitroimidazole compounds.
• Effect on Outcome of an Increase of Serum Cardiac Troponin T in Patients With Healing or Healed ST-Elevation Myocardial Infarction.
• Enhancement of synaptic transmission and nociceptive behaviour in HPC-1/syntaxin 1A knockout mice following peripheral nerve injury.
• Hetero subunit interaction and RNA recognition of yeast tRNA (m7G46) methyltransferase synthesized in a wheat germ cell-free translation system.
• Hydroxyl radical probing of tRNA (Gm18) methyltransferase [TrmH]-AdoMet-artificial tRNA ternary complex.
• Influence of the signal-to-noise ratio on the accuracy of IOLMaster measurements.
• Isolation of diacylglycerol-2-aminoethylphosphonate from Tetrahymena pyriformis.
• Long-term oral administration of dipyridamole improves both cardiac and physical status in patients with mild to moderate chronic heart failure: a prospective open-randomized study.
• Modified permanent middle cerebral artery occlusion rat model aiming to reduce variability in infarct size.
• Motor evoked potential mapping and monitoring by direct brainstem stimulation. Technical note.
• Nicardipine prolonged-release implants for preventing cerebral vasospasm after subarachnoid hemorrhage: effect and outcome in the first 100 patients.
• Perioperative plasma active and total ghrelin levels are reduced in acromegaly when compared with in nonfunctioning pituitary tumours even after normalization of serum GH.
• Rho-kinase activation in endothelial cells contributes to expansion of infarction after focal cerebral ischemia.
• Right-handed snakes: convergent evolution of asymmetry for functional specialization.
• Selective peripheral denervation of the levator scapulae muscle for laterocollic cervical dystonia.
• Sequence motif-specific assignment of two [2Fe-2S] clusters in rat xanthine oxidoreductase studied by site-directed mutagenesis.
• The carboxyl-terminus directs TAF(I)48 to the nucleus and nucleolus and associates with multiple nuclear import receptors.
• Vertebrate collagenase: direct extraction from animal skin and human synovial membrane.
• Visual emotional context modulates brain potentials elicited by unattended tones.
• [Current status and problems in approval of new anticancer drugs in Japan]
• [Jervell and Lange-Nielsen syndrome]