Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin.

Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin. Research Abstract Details 

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Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin. Abstract Text:

Jeannet,Marina Scheller, Scarpellino, Duboux,Noemie Gardiol,Jonathan Back,Fabien Kuttler,Ilaria Malanchi,Walter Birchmeier,Achim Leutz,Joerg Huelsken,Werner Held, Jeannet,Marina Scheller, Scarpellino, Duboux,Noemie Gardiol,Jonathan Back,Fabien Kuttler,Ilaria Malanchi,Walter Birchmeier,Achim Leutz,Joerg Huelsken,Werner Held,Grégoire Jeannet,Marina Scheller,Léonardo Scarpellino,Stéphane Duboux,Noemie Gardiol,Jonathan Back,Fabien Kuttler,Ilaria Malanchi,Walter Birchmeier,Achim Leutz,Joerg Huelsken,Werner Held,

The canonical Wnt signaling pathway plays key roles in stem-cell maintenance, progenitor cell expansion, and lineage decisions. Transcriptional responses induced by Wnt depend on the association of either beta-catenin or gamma-catenin with lymphoid enhancer factor/T cell factor transcription factors. Here we show that hematopoiesis, including thymopoiesis, is normal in the combined absence of beta- and gamma-catenin. Double-deficient hematopoietic stem cells maintain long-term repopulation capacity and multilineage differentiation potential. Unexpectedly, 2 independent ex vivo reporter gene assays show that Wnt signal transmission is maintained in double-deficient hematopoietic stem cells, thymocytes, or peripheral T cells. In contrast, Wnt signaling is strongly reduced in thymocytes lacking TCF-1 or in nonhematopoietic cells devoid of beta-catenin. These data provide the first evidence that hematopoietic cells can transduce canonical Wnt signals in the combined absence of beta- and gamma-catenin.

Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin. Publishing Authors By Initials

G Jeannet,M Scheller,L Scarpellino,S Duboux,N Gardiol,J Back,F Kuttler,I Malanchi,W Birchmeier,A Leutz,J Huelsken,W Held,G Jeannet,M Scheller,L Scarpellino,S Duboux,N Gardiol,J Back,F Kuttler,I Malanchi,W Birchmeier,A Leutz,J Huelsken,W Held,G Jeannet,M Scheller,L Scarpellino,S Duboux,N Gardiol,J Back,F Kuttler,I Malanchi,W Birchmeier,A Leutz,J Huelsken,W Held,

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Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Blood

VOLUME: 111

Page Numbers: 142-9

Journal Abbreviation: Blood

ISSN: 0006-4971

DAY: 28

MONTH: 09

YEAR: 2007

Long-term, multilineage hematopoiesis occurs in the combined absence of -catenin and {gamma}-catenin. Information

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LANGUAGE: eng

NlmUniqueID: 7603509

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