Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men.

Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Research Abstract Details 

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Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Abstract Text:

Scott D Moffat,Susan M Resnick,

We previously reported that high circulating free testosterone (T) was associated with better performance on tests of memory, executive function, and spatial ability, and with a reduced risk for Alzheimer's disease. In this study, we report that free T levels, measured on multiple occasions over 14 years, predict regional cerebral blood flow (rCBF) measured by PET in 40 older men. Voxel-based regression, indicated that higher Free T was associated with increased rCBF in the hippocampus bilaterally (extending to the parahippocampal gyrus on the right), anterior cingulate gyrus, and right inferior frontal cortex. Total T concentrations were positively correlated with rCBF in the left putamen, bilateral thalamus, and left inferior frontal cortex and negatively correlated with amygdala rCBF bilaterally. These findings suggest that endogenous T influences brain physiology in regions critical for memory and attention and provide one mechanism through which T may affect cognitive function.

Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Publishing Authors By Initials

SD Moffat,SM Resnick,

For similar tomography, emission-computed research abstracts see: tomography, emission-computed research

PUBMED ID PMID:

MEDLINE DATE:

Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Intr

Journal: Neurobiology of aging

VOLUME: 28

Page Numbers: 914-20

Journal Abbreviation:

ISSN: 1558-1497

DAY: 12

MONTH: 05

YEAR: 2006

Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 8100437

Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Keywords Mesh Terms:

KEYWORDS: Tomography, Emission-Computed

MESH TERMS: methods

Chemical & Substance for Abstract: Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men. Information

Substance Name: Testosterone

Registry Number: 58-22-0

Grant and Affiliation Information for Long-term measures of free testosterone predict regional cerebral blood flow patterns in elderly men.

AFFILIATION: Laboratory of Personality and Cognition, Intramural Research Program, National Institute on Aging, Baltimore, MD 21224, United States.

Country: United States

AGENCY: United States NIA

GRANT: N01-AG-3-2124

ACRONYM: AG

MEDLINETA: Neurobiol Aging

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