Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood.

Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Research Abstract Details 

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Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Abstract Text:

Psychological, endocrine and immune parameters were measured over a 6-month period in 14 healthy subjects who underwent an unpredictable acute emotional stress (e.g. sudden death of a loved one) compared with 14 controls who did not. Probands were profoundly stressed as assessed 10 days after bereavement by their scores on the Hamilton Rating Scales of Anxiety and Depression, adrenocorticotropin and cortisol plasma concentrations, and non-suppression in response to dexamethasone. Functional alterations of immune parameters, such as responsiveness of peripheral blood lymphocytes to mitogens, were found 40 days after bereavement. Despite a normal number of circulating lymphocyte subsets, the functional activity of natural killer (NK) cells was markedly reduced at day 40. Changes in the intracellular concentration of beta-endorphin in peripheral blood mononuclear cells correlated with anxiety and depression scores. Controls showed no changes in psychometric, endocrine and immune measures during the 6-month study. Cluster analysis revealed two groups of bereaved subjects with different patterns of immune and endocrine changes: (1) Five subjects, characterized by harm-avoidant temperament and long-lasting dysphoric mood, showed reduced responsiveness of peripheral blood lymphocytes to mitogens, decreased NK cell activity and non-suppression in response to dexamethasone that persisted for 6 months. (2) Nine subjects showed significant changes only during the early phase after bereavement. Our data suggest that the immunological consequences of stress do not simply overlap with psychological and endocrine alterations, and are particularly severe and long-lasting in a subgroup of subjects, indicating the importance of individual variability in the capacity to cope with stress.

Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Publishing Authors By Initials

For similar hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pro-opiomelanocortin: beta-endorphin research abstracts see: hormones, hormone substitutes, and hormone antagonists: hormones: peptide hormones: hypothalamic hormones: pro-opiomelanocortin: beta-endorphin research

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Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Psychiatry research

VOLUME: 121

Page Numbers: 145-58

Journal Abbreviation: Psychiatry Res

ISSN: 0165-1781

DAY: 1

MONTH: Dec

YEAR: 2003

Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Information

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LANGUAGE: eng

NlmUniqueID: 7911385

Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Keywords Mesh Terms:

KEYWORDS: beta-Endorphin

MESH TERMS: immunology

Chemical & Substance for Abstract: Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood. Information

Substance Name: beta-Endorphin

Registry Number: 60617-12-1

Grant and Affiliation Information for Long-term immune-endocrine effects of bereavement: relationships with anxiety levels and mood.

AFFILIATION: Centro Studi Farmaco-Tossico Dipendenze, AUSL, Via Spalato 2, Parma 43100, Italy. g.gerra@palazzochigi.it

Country: Ireland

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MEDLINETA: Psychiatry Res

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