Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy.

Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. Research Abstract Details 

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Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. Abstract Text:

Ken-ichi Mori,Koichiro Nomata,Mitsuru Noguchi,Jiro Eguchi,Nobuyuki Hayashi,Hiroshi Kanetake,Ken-ichi Mori,Koichiro Nomata,Mitsuru Noguchi,Jiro Eguchi,Nobuyuki Hayashi,Hiroshi Kanetake,

OBJECTIVES: Combined cisplatin-based intra-arterial chemotherapy and radiotherapy is an effective treatment for patients with locally invasive bladder carcinoma. We report long-term follow-up data regarding definitive treatment of locally invasive bladder carcinoma, regardless of whether bladder preservation was possible. METHODS: The follow-up data from 24 patients (18 males and six females; aged, 31-85 years; median, 73 years) with invasive bladder carcinoma, between 1993 and 2003, was examined. The clinical stages of the patients ranged T2-T4, all N0M0, and involved 13 patients at T2 (T2a, T2b), seven patients at T3 and four patients at T4. Combined cisplatin-based intra-arterial chemotherapy and radiotherapy was performed. RESULTS: The 5-year overall survival rate and cancer-specific survival rate for all patients were 81.6% and 85.6%, respectively. When the patients were divided into complete response (CR) of 10 patients and non-CR groups of 14 patients, the 5-year overall survival rate for the CR group was 87.5%, while that of the non-CR group was 78.6% (P = 0.58). The tumor grade of the CR group was significantly lower than that of the non-CR group (P = 0.01). When the non-CR group was divided into radical cystectomy and non-radical cystectomy groups, the 5-year overall survival rate for the radical cystectomy group (100%) was higher than that of the non-radical cystectomy group (70%). CONCLUSION: This combined chemo-radiotherapy was effective for local invasive bladder carcinoma, leading to the possibility of bladder preservation using this therapy.

Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. Publishing Authors By Initials

K Mori,K Nomata,M Noguchi,J Eguchi,N Hayashi,H Kanetake,K Mori,K Nomata,M Noguchi,J Eguchi,N Hayashi,H Kanetake,

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Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: International journal of urology : official journa

VOLUME: 14

Page Numbers: 591-4

Journal Abbreviation: Int. J. Urol.

ISSN: 0919-8172

DAY: 24

MONTH: Jul

YEAR: 2007

Long-term follow up of patients with invasive bladder carcinoma receiving combined cisplatin-based intra-arterial chemotherapy and radiotherapy. Information

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LANGUAGE: eng

NlmUniqueID: 9440237

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AFFILIATION: Division of Nephro-Urology, Department of Translational Medical Sciences, Course of Medical and Dental Sciences, Nagasaki University Graduate School of Biomedical Sciences, Sakamoto 1-7-1, Nagasaki 852-8501, Japan. moriyuuta@hotmail.com

Country: Australia

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MEDLINETA: Int J Urol

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