Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders.

Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Research Abstract Details 

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Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Abstract Text:

Roxanne Carr,Michael B Wasdell,Donald Hamilton,Margaret D Weiss,Roger D Freeman,Joseph Tai,Wop J Rietveld,James E Jan,

To date, there have been no prospective long-term studies of melatonin therapy in children. We report here data from a prospective follow-up study of 44 children with neurodevelopmental disabilities and treatment-resistant circadian rhythm sleep disorders (CRSD) who had participated in a placebo controlled, double blind cross-over trial of sustained-release melatonin. The follow-up study involved a structured telephone interview of caregivers every 3 months for upto 3.8 yr. The caregivers provided ratings of satisfaction, adverse effects, benefits, persistence with treatment and additional medications. Changes in melatonin dose were recorded. Open ended questions were included to capture caregivers' impressions and comments concerning melatonin therapy. Adverse reaction to melatonin therapy and development of tolerance were not evident. Better sleep was associated with reported improvement in health, behavior and learning. At the end of the study, the parental comments regarding the effectiveness of long-term melatonin therapy were highly positive. Parents whose children had sleep maintenance difficulties expressed a wish to have a commercially available controlled-release melatonin product which would promote sleep for 8-10 hr. Hypnotics for children with CRSD should be considered a second line of treatment for those who fail to respond to sleep hygiene and/or melatonin.

Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Publishing Authors By Initials

R Carr,MB Wasdell,D Hamilton,MD Weiss,RD Freeman,J Tai,WJ Rietveld,JE Jan,

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Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of pineal research

VOLUME: 43

Page Numbers: 351-9

Journal Abbreviation: J. Pineal Res.

ISSN: 0742-3098

DAY: 3

MONTH: Nov

YEAR: 2007

Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Long-term effectiveness outcome of melatonin therapy in children with treatment-resistant circadian rhythm sleep disorders.

AFFILIATION: Melatonin Research Group, Department of Psychiatry, BC Children's Hospital, Vancouver, BC, Canada.

Country: Denmark

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MEDLINETA: J Pineal Res

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