[Long-term complete remission after single therapy with gemtuzumab ozogamicin for refractory AML in an elderly patient]

[Long-term complete remission after single therapy with gemtuzumab ozogamicin for refractory AML in an elderly patient] Research Abstract Details 

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[Long-term complete remission after single therapy with gemtuzumab ozogamicin for refractory AML in an elderly patient] Abstract Text:

Kazuto Ogura,Takuya Machida,Miho Nara,Ko Mayama,Tomoaki Akagi,Kohmei Kubo,Kazuto Ogura,Takuya Machida,Miho Nara,Ko Mayama,Tomoaki Akagi,Kohmei Kubo,

Gemtuzumab ozogamicin (GO) is a humanized anti-CD33 monoclonal antibody conjugated to calicheamicin, that is rapidly internalized after binding to CD33. This is followed by intracellular release of calicheamicin, which induces double-stranded DNA breaks, cell cycle arrest, and apoptosis. So GO is a more selective agent for acute myeloid leukemia (AML), because the CD33 antigen is expressed on AML, while it is not expressed on normal hematopoietic stem cells and nonhematopoietic tissues. However, some studies indicated that this agent showed resistance to refractory AML cells via various mechanisms, and that there were no potent effects. In this study, we report a 76-year-old female with recurrent AML who responded to single therapy with GO, achieving complete remission for more than 1 year after the start of administration, although additional remission induction was impossible. The response to GO can be stratified with reference to the response to conventional chemotherapy.

[Long-term complete remission after single therapy with gemtuzumab ozogamicin for refractory AML in an elderly patient] Publishing Authors By Initials

K Ogura,T Machida,M Nara,K Mayama,T Akagi,K Kubo,K Ogura,T Machida,M Nara,K Mayama,T Akagi,K Kubo,

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[Long-term complete remission after single therapy with gemtuzumab ozogamicin for refractory AML in an elderly patient] Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Gan to kagaku ryoho. Cancer & chemotherapy

VOLUME: 34

Page Numbers: 1881-3

Journal Abbreviation: Gan To Kagaku Ryoho

ISSN: 0385-0684

DAY: 21

MONTH: Nov

YEAR: 2007

[Long-term complete remission after single therapy with gemtuzumab ozogamicin for refractory AML in an elderly patient] Information

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LANGUAGE: jpn

NlmUniqueID: 7810034

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AFFILIATION: Dept. of Hematology, Aomori Prefectural Central Hospital.

Country: Japan

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MEDLINETA: Gan To Kagaku Ryoho

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