Long-term aspirin use and mortality in women.

Long-term aspirin use and mortality in women. Research Abstract Details 

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Long-term aspirin use and mortality in women. Abstract Text:

BACKGROUND: The influence of long-term use of aspirin on total mortality in women remains uncertain. METHODS: We conducted a prospective, nested, case-control study of 79 439 women enrolled in the Nurses' Health Study who had no history of cardiovascular disease or cancer. Women provided data on medication use biennially since 1980. We assessed relative risk (RR) of death according to aspirin use before diagnosis of incident cardiovascular disease or cancer and during the corresponding period for each control subject. RESULTS: During 24 years, we documented 9477 deaths from all causes. In women who reported current aspirin use, the multivariate RR of death from all causes was 0.75 (95% confidence interval, 0.71-0.81) compared with women who never used aspirin regularly. The risk reduction was more apparent for death from cardiovascular disease (RR, 0.62; 95% confidence interval, 0.55-0.71) than for death from cancer (RR, 0.88; 95% confidence interval, 0.81-0.96). Use of aspirin for 1 to 5 years was associated with significant reductions in cardiovascular mortality (RR, 0.75; 95% confidence interval, 0.61-0.92). In contrast, a significant reduction in risk of cancer deaths was not observed until after 10 years of aspirin use (P(linear trend) = .005). The benefit associated with aspirin was confined to low and moderate doses and was significantly greater in older participants (P(interaction)< .001) and those with more cardiac risk factors (P(interaction) = .02). CONCLUSIONS: In women, low to moderate doses of aspirin are associated with significantly lower risk of all-cause mortality, particularly in older women and those with cardiac risk factors. A significant benefit is evident within 5 years for cardiovascular disease, whereas a modest benefit for cancer is not apparent until after 10 years of use.

Long-term aspirin use and mortality in women. Publishing Authors By Initials

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Long-term aspirin use and mortality in women. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Archives of internal medicine

VOLUME: 167

Page Numbers: 562-72

Journal Abbreviation: Arch. Intern. Med.

ISSN: 0003-9926

DAY: 26

MONTH: Mar

YEAR: 2007

Long-term aspirin use and mortality in women. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 372440

Long-term aspirin use and mortality in women. Keywords Mesh Terms:

KEYWORDS: United States

MESH TERMS: epidemiology

Chemical & Substance for Abstract: Long-term aspirin use and mortality in women. Information

Substance Name: Aspirin

Registry Number: 50-78-2

Grant and Affiliation Information for Long-term aspirin use and mortality in women.

AFFILIATION: Gastrointestinal Unit, Massachusetts General Hospital, Harvard Medical School, Boston, MA 0214, USA.

Country: United States

AGENCY: United States NHLBI

GRANT: HL 34594

ACRONYM: HL

MEDLINETA: Arch Intern Med

REFSOURCE: Arch Intern Med. 2007 Mar 26;167(6):535-

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