Long circulating superparamagnetic particles with high T2 relaxivity.

Long circulating superparamagnetic particles with high T2 relaxivity. Research Abstract Details 

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Long circulating superparamagnetic particles with high T2 relaxivity. Abstract Text:

S Pochon,R Hyacinthe,J Terrettaz,F Robert,M Schneider,H Tournier,

Novel superparamagnetic particles coated with a phospholipid and a surfactant were characterized and evaluated in vivo. These particles (SBPA) were shown to exhibit r2 relaxivities in the range of 350-450 mM-1.s-1, r1 values of 8-12 mM-1.s-1 and sizes of 50-80 nm. Preliminary results of pharmacokinetics were obtained in rats following the administration of 59Fe-labelled preparations. The particles were shown to remain for hours in the blood stream before being cleared mainly by the liver. Most of 59Fe was eliminated from the body and recovered in the feces within a week. These biodistribution and elimination properties deserve more detailed studies and suggest the potential use of this product as a blood pool contrast agent.

Long circulating superparamagnetic particles with high T2 relaxivity. Publishing Authors By Initials

S Pochon,R Hyacinthe,J Terrettaz,F Robert,M Schneider,H Tournier,

For similar biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research abstracts see: biochemical phenomena, metabolism, and nutrition: metabolism: pharmacokinetics: tissue distribution research

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Long circulating superparamagnetic particles with high T2 relaxivity. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Acta radiologica. Supplementum

VOLUME: 412

Page Numbers: 69-72

Journal Abbreviation:

ISSN: 0001-6926

DAY: 20

MONTH: 02

YEAR: 1997

Long circulating superparamagnetic particles with high T2 relaxivity. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 370370

Long circulating superparamagnetic particles with high T2 relaxivity. Keywords Mesh Terms:

KEYWORDS: Tissue Distribution

MESH TERMS: metabolism

Chemical & Substance for Abstract: Long circulating superparamagnetic particles with high T2 relaxivity. Information

Substance Name: Iron

Registry Number: 7439-89-6

Grant and Affiliation Information for Long circulating superparamagnetic particles with high T2 relaxivity.

AFFILIATION: Bracco Research SA, Geneva, Switzerland. pochon@bracco.ch

Country: DENMARK

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MEDLINETA: Acta Radiol Suppl

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