Location, location, location: the cancer stem cell niche.

Location, location, location: the cancer stem cell niche. Research Abstract Details 

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Location, location, location: the cancer stem cell niche. Abstract Text:

Julie B Sneddon,Zena Werb,

The existence of a stem cell niche, or physiological microenvironment, consisting of specialized cells that directly and indirectly participate in stem cell regulation has been verified for mammalian adult stem cells in the intestinal, neural, epidermal, and hematopoietic systems. In light of these findings, it has been proposed that a "cancer stem cell niche" also exists and that interactions with this tumor niche may specify a self-renewing population of tumor cells. We discuss emerging data that support the idea of a veritable cancer stem cell niche and propose several models for the relationship between cancer cells and their niches.

Location, location, location: the cancer stem cell niche. Publishing Authors By Initials

JB Sneddon,Z Werb,

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Location, location, location: the cancer stem cell niche. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Cell stem cell

VOLUME: 1

Page Numbers: 607-11

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ISSN: 1934-5909

DAY: 13

MONTH: Dec

YEAR: 2007

Location, location, location: the cancer stem cell niche. Information

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LANGUAGE: eng

NlmUniqueID: 101311472

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Grant and Affiliation Information for Location, location, location: the cancer stem cell niche.

AFFILIATION: Howard Hughes Medical Institute, Harvard University, Cambridge, MA 02138, USA. jsneddon@mcb.harvard.edu

Country: United States

AGENCY: United States Howard Hugh

GRANT: CA057621

ACRONYM: CA

MEDLINETA: Cell Stem Cell

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