Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited.

Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Research Abstract Details 

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Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Abstract Text:

James T Parsons,Bruce D Greene,Vinay Sharma,

AIMS: The purpose of this study was to review the treatment policy for locally advanced stage III and IV squamous cell carcinoma (SCC) of the tonsil at the Princess Alexandra Hospital Head and Neck Unit, Brisbane, Australia. MATERIALS AND METHODS: The records of 148 patients with curable stage III and IV SCC of the tonsil were reviewed from the years 1992 to 2004 inclusive. During this period, patients were treated with surgery and postoperative radiotherapy and only offered definitive radiation if they were medically or surgically inoperable. There were 102 patients treated with surgery +/- postoperative radiotherapy (group 1) and 46 patients treated with definitive radiotherapy +/- chemotherapy (group 2). The endpoints of locoregional control (LRC), disease specific survival (DSS), and overall survival (OS) were studied and prognostic factors were investigated with univariate and multivariate analyses. RESULTS: The 5-year OS, DSS, and LRC were 57%, 69%, and 84%, respectively. Univariate analyses showed that patients in group 1 had a superior OS (69% vs. 41%, P = .007), a trend toward improvement in LRC (88% vs. 73%, P = .08), and a nonsignificant improvement in DSS (75% vs. 56%, P = .14). There was a greater percentage of patients with an Eastern Cooperative Oncology Group (ECOG) score of 2 or less in group 1, suggesting selection bias toward the surgical group. Multivariate analyses, which adjusted for known prognostic factors, showed that treatment group was significant for OS but not for LRC or DSS. CONCLUSIONS: Surgery and postoperative radiotherapy continues to provide a superior outcome in locally advanced tonsil SCC in patients with surgically resectable disease, good ECOG performance status, and medically operable.

Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Publishing Authors By Initials

JT Parsons,BD Greene,V Sharma,

For similar neoplasms: neoplasms by site: head and neck neoplasms: otorhinolaryngologic neoplasms: pharyngeal neoplasms: oropharyngeal neoplasms: tonsillar neoplasms research abstracts see: neoplasms: neoplasms by site: head and neck neoplasms: otorhinolaryngologic neoplasms: pharyngeal neoplasms: oropharyngeal neoplasms: tonsillar neoplasms research

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Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: The Laryngoscope

VOLUME: 117

Page Numbers: 45-50

Journal Abbreviation: Laryngoscope

ISSN: 0023-852X

DAY: 19

MONTH: Jan

YEAR: 2007

Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Information

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LANGUAGE: eng

NlmUniqueID: 8607378

Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited. Keywords Mesh Terms:

KEYWORDS: Tonsillar Neoplasms

MESH TERMS: therapy

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Grant and Affiliation Information for Locally advanced tonsillar squamous cell carcinoma: Treatment approach revisited.

AFFILIATION: Southern Zone Radiation Oncology, Mater Queensland Radium Institute, South Brisbane, Australia. michael_poulsen@health.qld.gov.au

Country: United States

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MEDLINETA: Laryngoscope

REFSOURCE: Laryngoscope. 2007 Oct;117(10):1894-5; a

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