Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up.

Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up. Research Abstract Details 

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Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up. Abstract Text:

BACKGROUND:: Previously, it was shown that locally applied intraoperative ketorolac and bupivacaine significantly reduced pain in the recovery room. The objective of this study was to test the effectiveness of the same solution over the first 10 days. METHODS:: This study was a prospective, randomized, double-blind clinical trial with ethical approval. Fifty submuscular breast augmentation patients were enrolled, and informed consent was obtained. Standard anesthetic and surgical protocols were followed. Either normal saline or ketorolac and bupivacaine (30 mg and 150 mg, respectively) were placed into the pocket. The power of this study to detect a 20 percent difference was 0.90, and values of p < 0.05 were considered significant. The primary outcome was pain measured with the visual analogue pain scale recorded in a take-home diary. The secondary outcome was codeine usage. RESULTS:: Forty-five patients completed the study. Of the patients who did not, three were in the normal saline group (n = 22) and two were in the ketorolac-bupivacaine group (n = 23). The ketorolac-bupivacaine combination significantly reduced pain over the first 5 days. By the tenth day postoperatively, the effect had dissipated. These patients also used less codeine. There were no significant complications. CONCLUSION:: Locally applied, intraoperative ketorolac and bupivacaine significantly reduced pain for 5 days after surgery in women who had undergone primary breast augmentation.

Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up. Publishing Authors By Initials

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Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Plastic and reconstructive surgery

VOLUME: 121

Page Numbers: 638-43

Journal Abbreviation: Plast. Reconstr. Surg.

ISSN: 1529-4242

DAY: 27

MONTH: Feb

YEAR: 2008

Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up. Information

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LANGUAGE: eng

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Grant and Affiliation Information for Locally Administered Ketorolac and Bupivacaine for Control of Postoperative Pain in Breast Augmentation Patients: Part II. 10-Day Follow-Up.

AFFILIATION: Kelowna, British Columbia, Canada From the Division of Plastic and Reconstructive Surgery, and the Department of Anesthesia, Okanagan Health Surgical Unit, University of British Columbia, and the Kelowna General Hospital.

Country: United States

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MEDLINETA: Plast Reconstr Surg

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