Localizing recent adaptive evolution in the human genome.

Localizing recent adaptive evolution in the human genome. Research Abstract Details 

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Localizing recent adaptive evolution in the human genome. Abstract Text:

Scott H Williamson,Melissa J Hubisz,Andrew G Clark,Bret A Payseur,Carlos D Bustamante,Rasmus Nielsen,

Identifying genomic locations that have experienced selective sweeps is an important first step toward understanding the molecular basis of adaptive evolution. Using statistical methods that account for the confounding effects of population demography, recombination rate variation, and single-nucleotide polymorphism ascertainment, while also providing fine-scale estimates of the position of the selected site, we analyzed a genomic dataset of 1.2 million human single-nucleotide polymorphisms genotyped in African-American, European-American, and Chinese samples. We identify 101 regions of the human genome with very strong evidence (p < 10(-5)) of a recent selective sweep and where our estimate of the position of the selective sweep falls within 100 kb of a known gene. Within these regions, genes of biological interest include genes in pigmentation pathways, components of the dystrophin protein complex, clusters of olfactory receptors, genes involved in nervous system development and function, immune system genes, and heat shock genes. We also observe consistent evidence of selective sweeps in centromeric regions. In general, we find that recent adaptation is strikingly pervasive in the human genome, with as much as 10% of the genome affected by linkage to a selective sweep.

Localizing recent adaptive evolution in the human genome. Publishing Authors By Initials

SH Williamson,MJ Hubisz,AG Clark,BA Payseur,CD Bustamante,R Nielsen,

For similar genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research abstracts see: genetic phenomena: variation (genetics): polymorphism, genetic: polymorphism, single nucleotide research

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Localizing recent adaptive evolution in the human genome. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: PLoS genetics

VOLUME: 3

Page Numbers: e90

Journal Abbreviation: PLoS Genet.

ISSN: 1553-7404

DAY: 20

MONTH: 04

YEAR: 2007

Localizing recent adaptive evolution in the human genome. Information

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LANGUAGE: eng

NlmUniqueID: 101239074

Localizing recent adaptive evolution in the human genome. Keywords Mesh Terms:

KEYWORDS: Polymorphism, Single Nucleotide

MESH TERMS: genetics

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Grant and Affiliation Information for Localizing recent adaptive evolution in the human genome.

AFFILIATION: Department of Biological Statistics and Computational Biology, Cornell University, Ithaca, New York, United States of America. sw292@cornell.edu

Country: United States

AGENCY: United States NHGRI

GRANT: 1R01HG003229

ACRONYM: HG

MEDLINETA: PLoS Genet

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