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Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana).

Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Research Abstract Details 

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  • Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Abstract Text:

    h-q wuH-Q Wu,z-g liuZ-G Liu,b gaoB Gao,m liM Li,p-x ranP-X Ran,m xingM Xing,h-q wuH-Q Wu,z-g liuZ-G Liu,b gaoB Gao,m liM Li,p-x ranP-X Ran,m xingM Xing,

    Cockroach-derived materials are known to be a major source of potent aeroallergens, causing allergic respiratory diseases such as asthma and allergic rhinitis. The aim of this study was to determine the localization of the major allergen, Per a 3 (Cr-PI), within the American cockroach (Periplaneta americana), which might reveal the relative importance of excreted materials and nonexcreted cockroach components as allergen sources. American cockroaches (P. americana) and their faecal pellets were embedded in paraffin, and serial sections were cut and collected on glass slides. After being stained with mouse polyclonal antiserum against Per a 3, the sections were incubated sequentially with biotin-labelled sheep antimouse immunoglobulin G (IgG) and a preformed fluorescent isothiocyanate (FITC)-avidin complex. Finally, the sections were mounted and examined under a fluorescent microscope. Examination of Per a 3 immunoreactivity on the sections of the American cockroaches (P. americana) revealed that the midgut mucosa, gut contents and faecal pellets were all strongly labelled. Per a 3 immunoreactive products were not detected in any other internal organs of the American cockroaches. These results suggest that Per a 3 allergen might be synthesized in and secreted from the epithelia of the midgut mucosa and excreted from the body in the faecal pellets.

    Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Publishing Authors By Initials

    hq wuHQ Wu,zg liuZG Liu,b gaoB Gao,m liM Li,px ranPX Ran,m xingM Xing,hq wuHQ Wu,zg liuZG Liu,b gaoB Gao,m liM Li,px ranPX Ran,m xingM Xing,

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    Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Journal Published:

    PUBLICATION TYPE: Research Support, Non-U.S. Gov

    Journal: International journal of immunogenetics

    VOLUME: 34

    Page Numbers: 347-51

    Journal Abbreviation: Int. J. Immunogenet.

    ISSN: 1744-3121

    DAY: 11

    MONTH: Oct

    YEAR: 2007

    Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Information

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    LANGUAGE: eng

    NlmUniqueID: 101232337

    Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana). Keywords Mesh Terms:

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    Grant and Affiliation Information for Localization of Per a 3 allergen in the gut and faecal pellets of the American cockroach (Periplaneta americana).

    AFFILIATION: Allergy and Immunology Institute, Shenzhen University, Shenzhen, China.

    Country: England

    England Research PublicationEngland Research Publication

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    MEDLINETA: Int J Immunogenet

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