Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice.

Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice. Research Abstract Details 

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Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice. Abstract Text:

Hanqi Chu,Hao Xiong,Xiaoqin Zhou,Xiaowen Huang,Liangqiang Zhou,Yonghua Cui,

The distribution of the Na-K-2Cl co-transporter (NKCC1) in the cochlear K+ cycling pathway in cochlea and cochlear histological changes in the NKCC1 knockout mice were investigated. By using immunohistochemistry and toluidine blue staining, the localization of NKCC1 in cochlea of the C57BL/6J mice and the cochlear histological changes in the NKCC1 knockout mice were observed. It was found that the NKCC1 was expressed mainly in the stria marginal cells and the fibrocytes in the inferior portion of the spiral ligament in the adult C57BL/6J mice. Subpopulation of the fibrocytes in the suprastrial region and the limbus was also moderately immunoreactive. While in the cochlea of the NKCC1 knockout mice, Reissner's membrane was collapsed and scala media disappeared, accompanied with the loss of inner hair cells, outer hair cells and the support cells. The tunnel of Corti was often absent. All the findings suggested the localization of NKCC1 in the cochlea was closely correlated with cochlear K+ cycling. Loss of NKCC1 led to the destruction of the cochlear structures, and subsequently influenced the physiological function of cochlea.

Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice. Publishing Authors By Initials

H Chu,H Xiong,X Zhou,X Huang,L Zhou,Y Cui,

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Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of Huazhong University of Science and Tech

VOLUME: 26

Page Numbers: 374-7

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ISSN: 1672-0733

DAY: 11

MONTH: 09

YEAR: 2006

Localization of NKCC1 in the cochlea and morphology of the cochlea in NKCC1-knockout mice. Information

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LANGUAGE: eng

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AFFILIATION: Department of Otolaryngology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China.

Country: China

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MEDLINETA: J Huazhong Univ Sci Technolog

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