Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout.

Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Research Abstract Details 

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Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Abstract Text:

K M Lodhi,H Sakaguchi,S Hirose,H Hagiwara,

Endothelin (ET) receptors were identified in trout tissues that included the gill, heart, liver, kidney, and intestine. Since both the presence and the physiological function of endothelin-1 (ET-1) in trout gills have been determined, we examined the localization and characterization of ET receptors in the gills. Ligand specificity of the receptors, determined by using members of the endothelin family, revealed that endothelin receptors specific for ET-1 were predominant in the gills, but the binding sites of such receptors had low affinity for BQ-123, which is selective for mammalian endothelin A receptors (ETA). We propose that this subtype of receptor be called a fish-type ETA receptor (ETAF) to distinguish it from the mammalian ETA receptor. Affinity labeling of binding sites on gill membranes with 125I-labeled ET-1 and the cross-linking reagent 1,5-difluoro-2,4-dinitrobenzene revealed one major protein with an M(r) of 58,000, similar to that found in mammals. Autoradiographic studies demonstrated a high density of endothelin-binding sites in the lamellar sinusoid, which is involved in gas exchange in gills. No binding was detected in the chondrocytes or cartilaginous matrix. Our observations suggest that the endothelin and ET receptor system found in mammals might play a physiological role in the regulation of metabolic functions in fish.

Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Publishing Authors By Initials

KM Lodhi,H Sakaguchi,S Hirose,H Hagiwara,

For similar proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, endothelin research abstracts see: proteins: membrane proteins: receptors, cell surface: receptors, g-protein-coupled: receptors, endothelin research

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Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Journal of biochemistry

VOLUME: 118

Page Numbers: 376-9

Journal Abbreviation: J. Biochem.

ISSN: 0021-924X

DAY: 19

MONTH: Aug

YEAR: 1995

Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Information

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LANGUAGE: eng

NlmUniqueID: 376600

Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Keywords Mesh Terms:

KEYWORDS: Receptors, Endothelin

MESH TERMS: metabolism

Chemical & Substance for Abstract: Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout. Information

Substance Name: Receptors, Endothelin

Registry Number: 0

Grant and Affiliation Information for Localization and characterization of a novel receptor for endothelin in the gills of the rainbow trout.

AFFILIATION: Department of Biological Sciences, Tokyo Institute of Technology, Yokohama.

Country: JAPAN

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MEDLINETA: J Biochem

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