Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells.

Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Research Abstract Details 

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Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Abstract Text:

Brant R Ward,James V Jester,Akiko Nishibu,Mridula Vishwanath,David Shalhevet,Tadashi Kumamoto,W Matthew Petroll,H Dwight Cavanagh,Akira Takashima,

Langerhans cells (LCs) represent a special subset of immature dendritic cells (DCs) that reside in epithelial tissues at the environmental interfaces. Although dynamic interactions of mature DCs with T cells have been visualized in lymph nodes, the cellular behaviours linked with the surveillance of tissues for pathogenic signals, an important function of immature DCs, remain unknown. To visualize LCs in situ, bone marrow cells from C57BL/6 mice expressing the enhanced green fluorescent protein (EGFP) transgene were transplanted into syngeneic wild-type recipients. Motile activities of EGFP(+) corneal LCs in intact organ cultures were then recorded by time lapse two-photon microscopy. At baseline, corneal LCs exhibited a unique motion, termed dendrite surveillance extension and retraction cycling habitude (dSEARCH), characterized by rhythmic extension and retraction of their dendritic processes through intercellular spaces between epithelial cells. Upon pinpoint injury produced by infrared laser, LCs showed augmented dSEARCH and amoeba-like lateral movement. Interleukin (IL)-1 receptor antagonist completely abrogated both injury-associated changes, suggesting roles for IL-1. In the absence of injury, exogenous IL-1 caused a transient increase in dSEARCH without provoking lateral migration, whereas tumour necrosis factor-alpha induced both changes. Our results demonstrate rapid cytokine-mediated behavioural responses by LCs to local tissue injury, providing new insights into the biology of LCs.

Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Publishing Authors By Initials

BR Ward,JV Jester,A Nishibu,M Vishwanath,D Shalhevet,T Kumamoto,WM Petroll,HD Cavanagh,A Takashima,

For similar peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research abstracts see: peptides: intercellular signaling peptides and proteins: cytokines: monokines: tumor necrosis factor-alpha research

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Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Immunology

VOLUME: 120

Page Numbers: 556-72

Journal Abbreviation: Immunology

ISSN: 0019-2805

DAY: 22

MONTH: 01

YEAR: 2007

Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 374672

Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Keywords Mesh Terms:

KEYWORDS: Tumor Necrosis Factor-alpha

MESH TERMS: immunology

Chemical & Substance for Abstract: Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells. Information

Substance Name: Tumor Necrosis Factor-alpha

Registry Number: 0

Grant and Affiliation Information for Local thermal injury elicits immediate dynamic behavioural responses by corneal Langerhans cells.

AFFILIATION: Department of Dermatology, University of Texas South-western Medical Center, Dallas, TX, USA.

Country: England

AGENCY: United States NIAID

GRANT: T32-AI005284

ACRONYM: AI

MEDLINETA: Immunology

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