Local physiological changes during photodynamic therapy.

Local physiological changes during photodynamic therapy. Research Abstract Details 

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Local physiological changes during photodynamic therapy. Abstract Text:

Theresa M Busch,

BACKGROUND AND OBJECTIVE: Herein an overview is provided of the causes, consequences, and significance of photodynamic therapy (PDT)-mediated effects on tumor oxygenation and blood flow during illumination. STUDY DESIGN/MATERIALS AND METHODS: Techniques particularly valuable to this research have included tissue oxygen tension measurement by the Eppendorf pO2 Histograph; spatial quantification of hypoxia by EF3 and EF5; and tissue oxygenation/blood flow monitoring by diffuse reflectance/correlation spectroscopy. RESULTS: Severe hypoxia was measured in vivo during PDT and is shown to be a consequence of photochemical oxygen consumption and/or compromised vascular perfusion. Oxygen depletion can be controlled by treatment regimen, occurs in a spatially-definable pattern, and is therapy-limiting. PDT-induced changes in tumor oxygenation during illumination are correlated with outcome. In PDT-treated tissues, blood flow also is determined by treatment regimen and correlates with treatment response. CONCLUSIONS: Photodynamic therapy creates distinct, measurable changes in tumor oxygen and blood flow during illumination. These physiological changes may ultimately affect treatment efficacy.

Local physiological changes during photodynamic therapy. Publishing Authors By Initials

TM Busch,

For similar circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: regional blood flow research abstracts see: circulatory and respiratory physiology: cardiovascular physiology: cardiovascular physiologic processes: blood circulation: regional blood flow research

PUBMED ID PMID:

MEDLINE DATE:

Local physiological changes during photodynamic therapy. Journal Published:

PUBLICATION TYPE: Review

Journal: Lasers in surgery and medicine

VOLUME: 38

Page Numbers: 494-9

Journal Abbreviation:

ISSN: 0196-8092

DAY: 3

MONTH: Jun

YEAR: 2006

Local physiological changes during photodynamic therapy. Information

Number of References: 41

LANGUAGE: eng

NlmUniqueID: 8007168

Local physiological changes during photodynamic therapy. Keywords Mesh Terms:

KEYWORDS: Regional Blood Flow

MESH TERMS: metabolism

Chemical & Substance for Abstract: Local physiological changes during photodynamic therapy. Information

Substance Name: Reactive Oxygen Species

Registry Number: 0

Grant and Affiliation Information for Local physiological changes during photodynamic therapy.

AFFILIATION: Department of Radiation Oncology, School of Medicine, University of Pennsylvania, Philadelphia, Pennsylvania 19104-6072, USA. buschtm@mail.med.upenn.edu

Country: United States

AGENCY: United States NCI

GRANT: CA87971

ACRONYM: CA

MEDLINETA: Lasers Surg Med

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