Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study.

Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Research Abstract Details 

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Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Abstract Text:

R C Saunders,B S Kolachana,D R Weinberger,

The prefrontal cortex, caudate nucleus, and their dopaminergic innervations have been implicated in complex information processing. The present study utilized the in vivo microdialysis technique to characterize the extracellular dopamine levels in the prefrontal cortex and the caudate nucleus in the rhesus monkey. Basal levels of dopamine were consistently found in the caudate nucleus, while levels in the prefrontal cortex were less reliably measured. Manipulation of dopamine levels using tetrodotoxin and high potassium demonstrated that dopamine measured was dependent on neuronal firing. Administration of indirect dopamine agonists d-amphetamine and cocaine into the prefrontal cortex and the caudate nucleus increased extracellular dopamine levels 250% and 5000%, respectively. Amphetamine and cocaine had greater effects on dopamine levels in the caudate than in the prefrontal cortex. Cocaine induced increases appeared to be less than that of amphetamine and the actions of cocaine lasted longer than amphetamine. This study demonstrates the feasibility of using in vivo microdialysis in monitoring neurochemicals in different regions of the rhesus monkey brain.

Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Publishing Authors By Initials

RC Saunders,BS Kolachana,DR Weinberger,

For similar heterocyclic compounds: heterocyclic compounds, 2-ring: quinazolines: tetrodotoxin research abstracts see: heterocyclic compounds: heterocyclic compounds, 2-ring: quinazolines: tetrodotoxin research

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Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Experimental brain research. Experimentelle Hirnfo

VOLUME: 98

Page Numbers: 44-52

Journal Abbreviation:

ISSN: 0014-4819

DAY: 15

MONTH: 02

YEAR: 1994

Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Information

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LANGUAGE: eng

NlmUniqueID: 43312

Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Keywords Mesh Terms:

KEYWORDS: Tetrodotoxin

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study. Information

Substance Name: Potassium

Registry Number: 7440-09-7

Grant and Affiliation Information for Local pharmacological manipulation of extracellular dopamine levels in the dorsolateral prefrontal cortex and caudate nucleus in the rhesus monkey: an in vivo microdialysis study.

AFFILIATION: Clinical Brain Disorders Branch, NIMH/NIH, NIMH Neurosciences Center at St. Elizabeths Hospital, Washington, DC 20032.

Country: GERMANY

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MEDLINETA: Exp Brain Res

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