Local effects of antimuscarinics.

Local effects of antimuscarinics. Research Abstract Details 

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Local effects of antimuscarinics. Abstract Text:

Hitoshi Masuda,Yong-Tae Kim,Shachi Tyagi,Michael B Chancellor,Fernando de Miguel,Naoki Yoshimura,

Overactive bladder (OAB) syndrome has been estimated to occur in nearly 17% of the population. The most common drug treatments for OAB are antimuscarinic agents that act to increase bladder capacity and decrease the urge to urinate during the storage phase. An increasing number of studies have focused on te role and mechanism of muscarinic acetylcholine receptors for the regulation of afferent activity during urine storage. Interactions between muscarinic receptors in the urothelium, afferent nerves, or myofibroblasts and locally released acetylcholine might be involved in the emergence of detrusor overactivity and OAB. Therefore, antimuscarinic agents may be effective in treating OAB not only by suppression of muscarinic receptor-mediated detrusor muscle contractions but also by modulation of muscarinic receptor-bladder afferent interactions.

Local effects of antimuscarinics. Publishing Authors By Initials

H Masuda,YT Kim,S Tyagi,MB Chancellor,F de Miguel,N Yoshimura,

For similar male urogenital diseases: urologic diseases: urinary bladder diseases: urinary bladder, overactive research abstracts see: male urogenital diseases: urologic diseases: urinary bladder diseases: urinary bladder, overactive research

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MEDLINE DATE:

Local effects of antimuscarinics. Journal Published:

PUBLICATION TYPE: Review

Journal: The Urologic clinics of North America

VOLUME: 33

Page Numbers: 511-8, ix-x

Journal Abbreviation: Urol. Clin. North Am.

ISSN: 0094-0143

DAY: 3

MONTH: Nov

YEAR: 2006

Local effects of antimuscarinics. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 423221

Local effects of antimuscarinics. Keywords Mesh Terms:

KEYWORDS: Urinary Bladder, Overactive

MESH TERMS: drug therapy

Chemical & Substance for Abstract: Local effects of antimuscarinics. Information

Substance Name: Receptors, Muscarinic

Registry Number: 0

Grant and Affiliation Information for Local effects of antimuscarinics.

AFFILIATION: Department of Urology and Reproductive Medicine, Graduate School, Tokyo Medical and Dental University, Tokyo, Japan.

Country: United States

AGENCY: United States NICHD

GRANT: P01 HD39768

ACRONYM: HD

MEDLINETA: Urol Clin North Am

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