Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery.

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Research Abstract Details 

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Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Abstract Text:

Huiguang Zhu,Michael J McShane,

A straightforward method for loading hydrophobic materials into commercially available polymer nano- or microparticles is described. PMMA and PS nano/microparticles were swelled by an organic solvent with an ionic surfactant (SDS) to stabilize the particles in aqueous solution. FITC and Ru(dpp)3Cl2 were loaded into those particles based on the principle of "like dissolves like". Further surface modification of the loaded particles was achieved via layer-by-layer (LbL) self-assembly. Culture of fibroblasts with the dye-doped, coated particles showed that the cells internalized the fluorescent particles with no apparent toxic effects. The findings suggest the facile process could be useful in a wide range of applications for fluorescent micro/nanosensors and drug delivery.

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Publishing Authors By Initials

H Zhu,MJ McShane,

For similar macromolecular substances: polymers research abstracts see: macromolecular substances: polymers research

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MEDLINE DATE:

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Journal Published:

PUBLICATION TYPE: Research Support, U.S. Gov't,

Journal: Journal of the American Chemical Society

VOLUME: 127

Page Numbers: 13448-9

Journal Abbreviation: J. Am. Chem. Soc.

ISSN: 0002-7863

DAY: 5

MONTH: Oct

YEAR: 2005

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Information

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LANGUAGE: eng

NlmUniqueID: 7503056

Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Keywords Mesh Terms:

KEYWORDS: Polymers

MESH TERMS: chemistry

Chemical & Substance for Abstract: Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery. Information

Substance Name: Polymers

Registry Number: 0

Grant and Affiliation Information for Loading of hydrophobic materials into polymer particles: implications for fluorescent nanosensors and drug delivery.

AFFILIATION: Institute for Micromanufacturing and Biomedical Engineering Program, Louisiana Tech University, Ruston, Louisiana 71272, USA. hzhu@latech.edu

Country: United States

AGENCY: United States NIBIB

GRANT: R01 EB00739-01

ACRONYM: EB

MEDLINETA: J Am Chem Soc

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