Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Abstract Text:

Yanjun Liu,Chaoying Yan,Ying Wang,Yuichi Nakagawa,Namiko Nerio,Adrian Anghel,Kabirullah Lutfy,Theodore C Friedman,

The glucocorticoid receptor (GR) is a crucial target gene for glucocorticoid-induced insulin resistance and hepatic gluconeogenesis linked to the development of type 2 diabetes. The liver X receptors (LXRs) are nuclear receptors that play an important role in the regulation of the metabolic gene linked to carbohydrate homeostasis. To assess the tissue-specific interaction of LXR with GR in the development of type 2 diabetes, we examined the possible effect of LXR agonist T0901317 on GR gene expression in vivo and in vitro in hepatocytes from db/db mice (a model of type 2 diabetes). Chronic ligand activation of LXR by a synthetic LXR T0901317 markedly decreased the expression of both GR mRNA and its protein in liver and improved the phenotype of type 2 diabetes in obese db/db mice. Suppression of hepatic GR expression was correlated with reduced levels of glucose and corresponded to the inhibition of phosphoenolpyruvate carboxykinase mRNA and 11beta-hydroxysteroid dehydrogenase type 1-mediated synthesis of active corticosterone from inactive 11-dehydrocorticosterone in liver. Treatment of db/db mouse primary hepatocytes with T0901317 resulted in dramatic suppression of GR mRNA and required ongoing protein synthesis. Addition of T0901317 to primary hepatocytes also suppressed the expression of both 11beta-hydroxysteroid dehydrogenase type 1 and phosphoenolpyruvate carboxykinase. These findings suggest that some of antidiabetic actions of LXR agonist T0901317 may be mediated, at least in part, through the suppression of hepatic GR gene expression.

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Publishing Authors By Initials

Y Liu,C Yan,Y Wang,Y Nakagawa,N Nerio,A Anghel,K Lutfy,TC Friedman,

For similar organic chemicals: amides: sulfonamides research abstracts see: organic chemicals: amides: sulfonamides research

PUBMED ID PMID:

MEDLINE DATE:

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Endocrinology

VOLUME: 147

Page Numbers: 5061-8

Journal Abbreviation: Endocrinology

ISSN: 0013-7227

DAY: 27

MONTH: 07

YEAR: 2006

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375040

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Keywords Mesh Terms:

KEYWORDS: Sulfonamides

MESH TERMS: pharmacology

Chemical & Substance for Abstract: Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice. Information

Substance Name: Phosphoenolpyruvate Carboxykinase (ATP)

Registry Number: EC 4.1.1.49

Grant and Affiliation Information for Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.

AFFILIATION: Division of Endocrinology, Charles R. Drew University of Medicine and Sciences, University of California, Los Angeles, School of Medicine, 1731 East 120th Street, Los Angeles, California 90059, USA. dryanjunliu@hotmail.com

Country: United States

AGENCY: United States NCRR

GRANT: U54 RR-14616

ACRONYM: RR

MEDLINETA: Endocrinology

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice Related Publications

• Across-tissue expression and evolution of genes controlled by the Aire transcription factor.
• Bridging the gap between biological and clinical informatics in a graduate training program.
• Calcium: a role for neuroprotection and sustained adaptation.
• Cellular colocalization and coregulation between hypothalamic pro-TRH and prohormone convertases in hypothyroidism.
• Controversies in building a management algorithm for vestibular schwannomas.
• Convergence of HIV seroprevalence among injecting and non-injecting drug users in New York City.
• Correspondence of low mean shear and high harmonic content in the porcine iliac arteries.
• Development and adaptations of innate immunity in the gastrointestinal tract of the newly hatched chick.
• Diagnosis of hepatic fibrosis in patients with chronic hepatitis C.
• Disseminating natural language processed clinical narratives.
• Effect of vitamin A on the oxidative stability of broiler meat during storage: lack of interactions with vitamin E.
• Effects of age and sequence presentation rate on temporal order recognition.
• Expression, production and release of the Eis protein by Mycobacterium tuberculosis during infection of macrophages and its effect on cytokine secretion.
• Identification of a region on the outer surface of the CBFbeta-SMMHC myeloid oncoprotein assembly competence domain critical for multimerization.
• Idiopathic intracranial hypertension.
• Liver X receptor agonist T0901317 inhibition of glucocorticoid receptor expression in hepatocytes may contribute to the amelioration of diabetic syndrome in db/db mice.
• Measurement of Signal-to-Noise and Contrast-to-Noise in the fBIRN Multicenter Imaging Study.
• Molecular basis of hepatic fibrosis.
• Molecular level probing of preferential hydration and its modulation by osmolytes through the use of pyranine complexed to hemoglobin.
• Mortality and herpesvirus infections of the Pacific oyster Crassostrea gigas in Tomales Bay, California, USA.
• New York City injection drug users' memories of syringe-sharing patterns and changes during the peak of the HIV/AIDS epidemic.
• Nitrite reductase activity of sol-gel-encapsulated deoxyhemoglobin. Influence of quaternary and tertiary structure.
• Quantitative analysis of O6-alkylguanine-DNA alkyltransferase in malignant glioma.
• Rapid conformational dynamics of cytochrome P450 2E1 in a natural biological membrane environment.
• Repeated stress alters the ability of nicotine to activate the hypothalamic-pituitary-adrenal axis.
• Schistosoma japonicum reinfection after praziquantel treatment causes anemia associated with inflammation.
• Sharing of transcription factors after gene duplication in the yeast Saccharomyces cerevisiae.
• T-cell receptor Valpha spectratype analysis of a CD4-mediated T-cell response against minor histocompatibility antigens involved in severe graft-versus-host disease.
• Variable intensity of purifying selection on cytotoxic T-lymphocyte epitopes in hepatitis C virus.
• Visual novel stimuli in an ERP novelty oddball paradigm: effects of familiarity on repetition and recognition memory.