Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years.

Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years. Research Abstract Details 

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Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years. Abstract Text:

S Yamamoto,H E Wilczek,G Nowak,M Larsson,A Oksanen,T Iwata,H Gjertsen,G ,L ,Y Ando,O B Suhr,B-G Ericzon,S Yamamoto,H E Wilczek,G Nowak,M Larsson,A Oksanen,T Iwata,H Gjertsen,G ,L ,Y Ando,O B Suhr,B-G Ericzon,S Yamamoto,H E Wilczek,G Nowak,M Larsson,A Oksanen,T Iwata,H Gjertsen,G ,L ,Y Ando,O B Suhr,B-G Ericzon,

Orthotopic liver transplantation (LTx) is currently the only available treatment that has been proven to halt the progress of familial amyloidotic polyneuropathy (FAP). The aim of this study was to assess mortality and symptomatic response to LTx for FAP. All 86 FAP patients transplanted at our hospital between April 1990 and November 2005 were included in the study. Five patients underwent retransplantation. The 1-, 3- and 5-year patient survival rates in patients transplanted during 1996-2005 were 94.6%, 92.3% and 92.3%, respectively, a significant difference from the rates of 76.7%, 66.7% and 66.7%, respectively, during 1990-1995 (p = 0.0003). Multivariate analysis revealed that the age at the time of LTx (>or=40 years), duration of the disease (>or=7 years) and modified body mass index (mBMI) (<600) were independent prognostic factors for patient survival. A halt in the progress of symptoms was noted in most patients, but only a minority experienced an improvement after LTx. To optimize the posttransplant prognosis, LTx should be performed in the early stages of the disease, and close post-LTx monitoring of heart function by echocardiography and of heart arrhythmia by Holter ECG is mandatory.

Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years. Publishing Authors By Initials

S Yamamoto,HE Wilczek,G Nowak,M Larsson,A Oksanen,T Iwata,H Gjertsen,G ,L ,Y Ando,OB Suhr,BG Ericzon,S Yamamoto,HE Wilczek,G Nowak,M Larsson,A Oksanen,T Iwata,H Gjertsen,G ,L ,Y Ando,OB Suhr,BG Ericzon,S Yamamoto,HE Wilczek,G Nowak,M Larsson,A Oksanen,T Iwata,H Gjertsen,G ,L ,Y Ando,OB Suhr,BG Ericzon,

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Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: American journal of transplantation : official jou

VOLUME: 7

Page Numbers: 2597-604

Journal Abbreviation: Am. J. Transplant.

ISSN: 1600-6135

DAY: 14

MONTH: 09

YEAR: 2007

Liver transplantation for familial amyloidotic polyneuropathy (FAP): a single-center experience over 16 years. Information

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LANGUAGE: eng

NlmUniqueID: 100968638

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AFFILIATION: Division of Transplantation Surgery, Department of Clinical Science, Intervention and Technology, Karolinska Institute, Karolinska University Hospital, Huddinge, Stockholm, Sweden. Shinji.Yamamoto@ki.se

Country: Denmark

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MEDLINETA: Am J Transplant

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