Liver-specific growth factors.

Liver-specific growth factors. Research Abstract Details 

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Liver-specific growth factors. Abstract Text:

W E Fleig,

Experimental evidence of the existence of liver-specific growth factors has been collected for more than two decades. Blood-borne growth-promoting activity of hepatocytes may be separated into plasma and platelet-derived factors. Several groups have observed the stimulation of hepatocyte growth in vitro by some platelet-associated activity, which was recently isolated from rat platelets as a 27-kDa protein called platelet growth factor (PGF). There is evidence of at least two different growth factors for hepatocytes derived from platelet-poor rat plasma, 'hepatopoietin' A and B. The partial purification of several other factors has been reported. One of these factors was prepared from the plasma of patients with fulminant hepatic failure. In addition to these 'humoral' factors, cytosolic growth-promoting activity has been partially purified by several groups. While the humoral factors described so far are only active on normal hepatocytes, the cytosolic 'hepatic stimulator substance' (HSS) also promotes the proliferation of differentiated hepatoma cells. In addition, it appears to depend on the permissive action of epidermal growth factor (EGF). None of the liver-specific growth factors except PGF has been purified to homogeneity. Thus, their significance for the control of the proliferation of normal and transformed hepatocytes is still an unsettled issue.

Liver-specific growth factors. Publishing Authors By Initials

WE Fleig,

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Liver-specific growth factors. Journal Published:

PUBLICATION TYPE: Review

Journal: Scandinavian journal of gastroenterology. Suppleme

VOLUME: 151

Page Numbers: 31-6

Journal Abbreviation: Scand. J. Gastroenterol. Suppl

ISSN: 0085-5928

DAY: 13

MONTH: 02

YEAR: 1988

Liver-specific growth factors. Information

Number of References: 50

LANGUAGE: eng

NlmUniqueID: 437034

Liver-specific growth factors. Keywords Mesh Terms:

KEYWORDS: Proteins

MESH TERMS: physiology

Chemical & Substance for Abstract: Liver-specific growth factors. Information

Substance Name: Hepatocyte Growth Factor

Registry Number: 67256-21-7

Grant and Affiliation Information for Liver-specific growth factors.

AFFILIATION: Dept. of Internal Medicine II (Gastroenterology and Nutrition), University of Ulm, FRG.

Country: NORWAY

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MEDLINETA: Scand J Gastroenterol Suppl

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