Liver receptor homologue-1 regulates gonadotrope function.

Liver receptor homologue-1 regulates gonadotrope function. Research Abstract Details 

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Liver receptor homologue-1 regulates gonadotrope function. Abstract Text:

Weiming Zheng,Jingying Yang,Qiaorong Jiang,Zhibin He,Lisa M Halvorson,

Over the past decade, substantial advances have been made in our understanding of the transcription factors which regulate gene expression in gonadotropes. One of the most important of these factors, steroidogenic factor-1 (SF-1; NR5A1) is critical for gonadotropin and GnRH-receptor expression. Interestingly, a closely related nuclear hormone receptor, liver receptor homologue-1 (LRH-1; NR5A2) has recently been detected in the anterior pituitary gland; however, its functional significance in this tissue has not been investigated. For the experiments reported here, we hypothesized that LRH-1 plays a previously unrecognized role in gonadotrope physiology. Towards this end, we first demonstrate LRH-1 mRNA and protein expression in both primary pituitary cells and gonadotrope-derived cell lines. We next show that LRH-1 stimulates promoter activity of the GnRH-receptor and gonadotropin subunit genes. Within the LHbeta gene, this response appears to be mediated by DNA-binding and transactivation through previously characterized SF-1 cis-elements. To our knowledge, this is the first report demonstrating a functional role for LRH-1 in the gonadotrope population of the anterior pituitary gland.

Liver receptor homologue-1 regulates gonadotrope function. Publishing Authors By Initials

W Zheng,J Yang,Q Jiang,Z He,LM Halvorson,

For similar proteins: receptors, cytoplasmic and nuclear research abstracts see: proteins: receptors, cytoplasmic and nuclear research

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Liver receptor homologue-1 regulates gonadotrope function. Journal Published:

PUBLICATION TYPE: Research Support, N.I.H., Extr

Journal: Journal of molecular endocrinology

VOLUME: 38

Page Numbers: 207-19

Journal Abbreviation: J. Mol. Endocrinol.

ISSN: 0952-5041

DAY: 3

MONTH: Feb

YEAR: 2007

Liver receptor homologue-1 regulates gonadotrope function. Information

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LANGUAGE: eng

NlmUniqueID: 8902617

Liver receptor homologue-1 regulates gonadotrope function. Keywords Mesh Terms:

KEYWORDS: Receptors, Cytoplasmic and Nuclear

MESH TERMS: physiology

Chemical & Substance for Abstract: Liver receptor homologue-1 regulates gonadotrope function. Information

Substance Name: Receptors, Cytoplasmic and Nuclear

Registry Number: 0

Grant and Affiliation Information for Liver receptor homologue-1 regulates gonadotrope function.

AFFILIATION: Division of Reproductive Endocrinology, Department of Obstetrics and Gynecology, University of Texas Southwestern Medical Center, Dallas, Texas 75390-9032, USA.

Country: England

AGENCY: United States NICHD

GRANT: R01 HD38089

ACRONYM: HD

MEDLINETA: J Mol Endocrinol

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