Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).

Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Research Abstract Details 

Research Abstract Table of Contents

Jump to the:

Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Abstract Text:

Kaye M Reid,Allan Tsung,Takahashi Kaizu,Geetha Jeyabalan,Atsushi Ikeda,Lifang Shao,Guoyao Wu,Noriko Murase,David A Geller,

Liver ischemia-reperfusion (I/R) injury is associated with profound arginine depletion due to arginase release from injured hepatocytes. The purpose of this study was to determine whether arginase inhibition with N(omega)-hydroxy-nor-l-arginine (nor-NOHA) would increase circulating arginine levels and decrease hepatic damage during liver I/R injury. The effects of nor-NOHA were initially tested in normal animals to determine in vivo toxicity. In the second series of experiments, orthotopic syngeneic liver transplantation (OLT) was performed after 18 h of cold ischemia time in Lewis rats. Animals were given nor-NOHA (100 mg/kg) or saline before and after graft reperfusion. In normal animals treated with nor-NOHA, there were no histopathological changes to organs, liver enzymes, serum creatinine, or body weight. In the OLT model, animals treated with saline exhibited markedly elevated serum transaminases and circulating arginase protein levels. Nor-NOHA administration blunted the increase in serum arginase activity by 80% and preserved serum arginine levels at 3 h after OLT. Nor-NOHA treatment reduced post-OLT serum liver enzyme release by 50%. Liver histology (degree of necrosis) in nor-NOHA-treated animals was markedly improved compared with the saline-treated group. Furthermore, use of the arginase inhibitor nor-NOHA did not influence polyamine synthesis owing to the decrease in ornithine levels. Arginase blockade represents a potentially novel strategy to combat hepatic I/R injury associated with liver transplantation.

Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Publishing Authors By Initials

KM Reid,A Tsung,T Kaizu,G Jeyabalan,A Ikeda,L Shao,G Wu,N Murase,DA Geller,

For similar organic chemicals: amines: biogenic amines: biogenic polyamines: putrescine: spermidine: spermine research abstracts see: organic chemicals: amines: biogenic amines: biogenic polyamines: putrescine: spermidine: spermine research

PUBMED ID PMID:

MEDLINE DATE:

Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: American journal of physiology. Gastrointestinal a

VOLUME: 292

Page Numbers: G512-7

Journal Abbreviation: Am. J. Physiol. Gastrointest.

ISSN: 0193-1857

DAY: 5

MONTH: 10

YEAR: 2006

Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 100901227

Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Keywords Mesh Terms:

KEYWORDS: Spermine

MESH TERMS: blood

Chemical & Substance for Abstract: Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA). Information

Substance Name: Arginase

Registry Number: EC 3.5.3.1

Grant and Affiliation Information for Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).

AFFILIATION: Department of Surgery, Univ of Pittsburgh, Pittsburgh, PA 15213, USA.

Country: United States

AGENCY: United States NIGMS

GRANT: R01-GM52021

ACRONYM: GM

MEDLINETA: Am J Physiol Gastrointest Live

REFSOURCE:

DATABASENAME:

ACCESSION NUMBER:

Number Hits: 0

Liver I/R injury is improved by the arginase inhibitor, Nomega-hydroxy-nor-L-arginine nor-NOHA Related Publications

• A neuropsychiatry service in a state hospital. Adolf Meyer's approach revisited.
• A randomized controlled effectiveness trial of acceptance and commitment therapy and cognitive therapy for anxiety and depression.
• A statistical analysis of 480 Army psychiatric casualties.
• Basic skills for working with smokers: a pilot test of an online course for medical students.
• Children's and parents' perspectives on open-label use of placebos in the treatment of ADHD.
• Continuous thermoacoustic mixture separation.
• Controlled study of switching from attention-deficit/hyperactivity disorder to a prepubertal and early adolescent bipolar I disorder phenotype during 6-year prospective follow-up: rate, risk, and predictors.
• Differential interaction of RU486 with the progesterone and glucocorticoid receptors.
• Glutamatergic or GABAergic neuron-specific, long-term expression in neocortical neurons from helper virus-free HSV-1 vectors containing the phosphate-activated glutaminase, vesicular glutamate transporter-1, or glutamic acid decarboxylase promoter.
• Glycochenodeoxycholate (GCDC) inhibits cytokine induced iNOS expression in rat hepatocytes.
• How to build your dream practice using Internet marketing--by breaking every rule.
• Hydrodynamic plasmid DNA gene therapy model in liver transplantation.
• Identification of a classic cytokine-induced enhancer upstream in the human iNOS promoter.
• Increased cancer risk for individuals with a family history of prostate cancer, colorectal cancer, and melanoma and their associated screening recommendations and practices.
• Inhibiting glycosaminoglycan chain polymerization decreases the inhibitory activity of astrocyte-derived chondroitin sulfate proteoglycans.
• Isolation of an enhancer from the rat tyrosine hydroxylase promoter that supports long-term, neuronal-specific expression from a neurofilament promoter, in a helper virus-free HSV-1 vector system.
• Liver I/R injury is improved by the arginase inhibitor, N(omega)-hydroxy-nor-L-arginine (nor-NOHA).
• Moving forward: human papillomavirus vaccination and the prevention of cervical cancer.
• Pathogenesis and medical treatment of benign prostatic hyperplasia.
• Prompting safety-belt use in the context of a belt-use law: the flash-for life revisited.
• Right Hemihepatectomy for Metastatic Cloacogenic Carcinoma using the Staple Technique.
• Right hepatic lobectomy using the staple technique in 101 patients.
• Risk factors for breast carcinoma in situ versus invasive breast cancer in a prospective study of pre- and post-menopausal women.
• Seizures and altered mental status after lamotrigine overdose.
• Testing association for markers on the X chromosome.
• Thermoacoustics and thermal dissociation of water.
• Transcriptional suppression of cytokine-induced iNOS gene expression by IL-13 through IRF-1/ISRE signaling.
• [External environment-leading factor in adaptability of the organism.]
• [Not Available.]
• [On prolonged antibacterial treatment of patients with fresh forms of destructive pulmonary tuberculosis.]