Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression.

Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Research Abstract Details 

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Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Abstract Text:

Johan Svensson,Asa Tivesten,Klara ,Olle Isaksson, ,Subburaman Mohan,Johan , Isgaard,Claes Ohlsson,

The GH/-IGF-I axis is important for kidney size and function and may also be involved in the development of renal failure. In this study, the role of liver-derived endocrine IGF-I for kidney size and function was investigated in mice with adult liver-specific IGF-I inactivation (LI-IGF-I(-/-) mice). These mice have an 80-85% reduction of serum IGF-I level and compensatory increased GH secretion. Seven-month-old as well as 24-month-old LI-IGF-I(-/-) mice had decreased kidney weight. Glomerular filtration rate, assessed using creatinine clearance as well as creatinine clearance corrected for body weight, was unchanged. The 24-h urine excretion of sodium and potassium was increased in the LI-IGF-I(-/-) mice. In the 24-month-old mice, there was no between-group difference in kidney morphology. Microarray and real-time PCR (RT-PCR) analyses showed a high renal expression of IGF-II in the control mice, whereas in the LI-IGF-I(-/-) mice, there was a tissue-specific decrease in the renal IGF-II mRNA levels (-79%, P < 0.001 vs controls using RT-PCR). In conclusion, deficiency of circulating liver-derived IGF-I in mice results, despite an increase in GH secretion, in a global symmetrical decrease in kidney size, increased urinary sodium and potassium excretion, and a clear down regulation of renal IGF-II expression. However, the LI-IGF-I(-/-) mice did not develop kidney failure or nephrosclerosis. One may speculate that liver-derived endocrine IGF-I induces renal IGF-II expression, resulting in symmetrical renal growth.

Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Publishing Authors By Initials

J Svensson,A Tivesten,K ,O Isaksson,G ,S Mohan,J ,J Isgaard,C Ohlsson,

For similar inorganic chemicals: elements: metals, alkali: sodium research abstracts see: inorganic chemicals: elements: metals, alkali: sodium research

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Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: The Journal of endocrinology

VOLUME: 193

Page Numbers: 359-66

Journal Abbreviation: J. Endocrinol.

ISSN: 0022-0795

DAY: 3

MONTH: Jun

YEAR: 2007

Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Information

Number of References:

LANGUAGE: eng

NlmUniqueID: 375363

Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Keywords Mesh Terms:

KEYWORDS: Sodium

MESH TERMS: urine

Chemical & Substance for Abstract: Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression. Information

Substance Name: GTP-Binding Proteins

Registry Number: EC 3.6.1.-

Grant and Affiliation Information for Liver-derived IGF-I regulates kidney size, sodium reabsorption, and renal IGF-II expression.

AFFILIATION: Department of Internal Medicine, Sahlgrenska University Hospital, Gröna Stråket 8, SE-413 45 Göteborg, Sweden.

Country: England

AGENCY: United States NIAMS

GRANT: AR048139

ACRONYM: AR

MEDLINETA: J Endocrinol

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