Live vaccines for human metapneumovirus designed by reverse genetics.

Live vaccines for human metapneumovirus designed by reverse genetics. Research Abstract Details 

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Live vaccines for human metapneumovirus designed by reverse genetics. Abstract Text:

Ursula J Buchholz,Kunio Nagashima,Brian R Murphy,Peter L Collins,

Human metapneumovirus (HMPV) was first described in 2001 and has quickly become recognized as an important cause of respiratory tract disease worldwide, especially in the pediatric population. A vaccine against HMPV is required to prevent severe disease associated with infection in infancy. The primary strategy is to develop a live-attenuated virus for intranasal immunization, which is particularly well suited against a respiratory virus. Reverse genetics provides a means of developing highly characterized 'designer' attenuated vaccine candidates. To date, several promising vaccine candidates have been developed, each using a different mode of attenuation. One candidate involves deletion of the G glycoprotein, providing attenuation that is probably based on reduced efficiency of attachment. A second candidate involves deletion of the M2-2 protein, which participates in regulating RNA synthesis and whose deletion has the advantageous property of upregulating transcription and increasing antigen synthesis. A third candidate involves replacing the P protein gene of HMPV with its counterpart from the related avian metapneumovirus, thereby introducing attenuation owing to its chimeric nature and host range restriction. Another live vaccine strategy involves using an attenuated parainfluenza virus as a vector to express HMPV protective antigens, providing a bivalent pediatric vaccine. Additional modifications to provide improved vaccines will also be discussed.

Live vaccines for human metapneumovirus designed by reverse genetics. Publishing Authors By Initials

UJ Buchholz,K Nagashima,BR Murphy,PL Collins,

For similar complex mixtures: biological products: vaccines: viral vaccines research abstracts see: complex mixtures: biological products: vaccines: viral vaccines research

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MEDLINE DATE:

Live vaccines for human metapneumovirus designed by reverse genetics. Journal Published:

PUBLICATION TYPE: Review

Journal: Expert review of vaccines

VOLUME: 5

Page Numbers: 695-706

Journal Abbreviation:

ISSN: 1744-8395

DAY: 3

MONTH: Oct

YEAR: 2006

Live vaccines for human metapneumovirus designed by reverse genetics. Information

Number of References: 80

LANGUAGE: eng

NlmUniqueID: 101155475

Live vaccines for human metapneumovirus designed by reverse genetics. Keywords Mesh Terms:

KEYWORDS: Viral Vaccines

MESH TERMS: immunology

Chemical & Substance for Abstract: Live vaccines for human metapneumovirus designed by reverse genetics. Information

Substance Name: Viral Vaccines

Registry Number: 0

Grant and Affiliation Information for Live vaccines for human metapneumovirus designed by reverse genetics.

AFFILIATION: Laboratory of Infectious Diseases, National Institute of Allergy and Infectious Diseases, National Institutes of Health, Building 50, Room 6505, 50 South Dr. MSC 8007, Bethesda, MD 20892-8007, USA. ubuchholz@niaid.nih.gov

Country: England

AGENCY: United States NCI

GRANT: N01-CO-12400

ACRONYM: CO

MEDLINETA: Expert Rev Vaccines

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