LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway.

LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Research Abstract Details 

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LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Abstract Text:

Le Zhao,Wei Chen,Kathryn M Taylor,Bin Cai,Xu Li,Le Zhao,Wei Chen,Kathryn M Taylor,Bin Cai,Xu Li,

It was reported that expression of the estrogen-regulated zinc transporter LIV-1 was particularly high in human cervical cancer cell line HeLa. This result prompted us to study the role that LIV-1 played in human cervical cancer. The results of real-time PCR showed that LIV-1 mRNA was significantly higher in cervical cancer in situ than in normal tissues. RNAi mediated suppression of LIV-1 in HeLa cells significantly inhibited cell proliferation, colony formation, migration, and invasive ability, but had no effect on cell apoptosis. Furthermore, LIV-1 suppression is accompanied by down-regulation of p44/42 MAPK, phospho-p44/42 MAPK, Snail and Slug expression levels. Hence, our data provide the first evidence that LIV-1 mRNA is overexpressed in cervical cancer in situ and is involved in invasion of cervical cancer cells through targeting MAPK-mediated Snail and Slug expression.

LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Publishing Authors By Initials

L Zhao,W Chen,KM Taylor,B Cai,X Li,L Zhao,W Chen,KM Taylor,B Cai,X Li,

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LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Journal Published:

PUBLICATION TYPE: Journal Article

Journal: Biochemical and biophysical research communication

VOLUME: 363

Page Numbers: 82-8

Journal Abbreviation: Biochem. Biophys. Res. Commun.

ISSN: 0006-291X

DAY: 30

MONTH: 08

YEAR: 2007

LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway. Information

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LANGUAGE: eng

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Grant and Affiliation Information for LIV-1 suppression inhibits HeLa cell invasion by targeting ERK1/2-Snail/Slug pathway.

AFFILIATION: Center for Laboratory Medicine, The First Affiliated Hospital, School of Medicine, Xi'an Jiaotong University, Xi'an, China.

Country: United States

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MEDLINETA: Biochem Biophys Res Commun

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