Lipoprotein(a) in children and adolescence.

Lipoprotein(a) in children and adolescence. Research Abstract Details 

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Lipoprotein(a) in children and adolescence. Abstract Text:

Lipoprotein(a) [Lp(a)], an LDL-like lipoprotein, has an additional carrier protein - apo (a), which closely resembles plasminogen. Epidemiological and experimental studies provide overwhelming evidence that Lp(a) may promote atherogenesis and thrombosis via its LDL-like and plasminogen-like mechanisms. With more than 90% variance explainable by the apo(a) gene, Lp(a) is detectable at birth and increases with age until adolescence when the Lp(a) reaches adult levels. There is a striking close offspring-parental correlation in Lp(a) levels, which is present at birth and tracks for life. While Lp(a) levels are highly regulated genetically and difficult to change, it appears that factors during the first year of life may have more impact on Lp(a) expression profiles, which possibly have long-lasting effects. Lp(a) levels are elevated in children with obesity, diabetes, renal diseases, hypercholesterolemia and are predictive of vascular diseases in themselves and other family members. We suggest that Lp(a) should be routinely measured in both children and adults for vascular disease risk factor assessment, at least among those with high conventional Coronary Artery Disease (CAD) risk factors and those with established CAD.

Lipoprotein(a) in children and adolescence. Publishing Authors By Initials

For similar cardiovascular diseases: vascular diseases research abstracts see: cardiovascular diseases: vascular diseases research

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Lipoprotein(a) in children and adolescence. Journal Published:

PUBLICATION TYPE: Review

Journal: Pediatric endocrinology reviews : PER

VOLUME: 1

Page Numbers: 109-19

Journal Abbreviation:

ISSN: 1565-4753

DAY: 9

MONTH: Dec

YEAR: 2003

Lipoprotein(a) in children and adolescence. Information

Number of References: 148

LANGUAGE: eng

NlmUniqueID: 101202124

Lipoprotein(a) in children and adolescence. Keywords Mesh Terms:

KEYWORDS: Vascular Diseases

MESH TERMS: metabolism

Chemical & Substance for Abstract: Lipoprotein(a) in children and adolescence. Information

Substance Name: Lipoprotein(a)

Registry Number: 0

Grant and Affiliation Information for Lipoprotein(a) in children and adolescence.

AFFILIATION: Cardiothoracic Surgery, Michael E. DeBakey Department of Surgery, Baylor College of Medicine, Houston, Texas 77030, USA. xlwang@bcm.tmc.edu

Country: Israel

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MEDLINETA: Pediatr Endocrinol Rev

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