Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression.

Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression. Research Abstract Details 

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Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression. Abstract Text:

N Koide,A Morikawa,G Tumurkhuu,J Dagvadorj,F Hassan,S Islam,Y Naiki,I Mori,T Yoshida,T Yokochi,N Koide,A Morikawa,G Tumurkhuu,J Dagvadorj,F Hassan,S Islam,Y Naiki,I Mori,T Yoshida,T Yokochi,N Koide,A Morikawa,G Tumurkhuu,J Dagvadorj,F Hassan,S Islam,Y Naiki,I Mori,T Yoshida,T Yokochi,

The effect of interferon (IFN)-gamma and/or lipopolysaccharide (LPS) on Fas-mediated cell death with anti-Fas agonistic antibody in vascular endothelial cells was examined using a mouse END-D cell line. Anti-Fas agonistic antibody exhibited cytotoxic actions on END-D cells. Fas-mediated cell death was enhanced by LPS or IFN-gamma. The combination of IFN-gamma and LPS significantly enhanced cell death compared to IFN-gamma or LPS alone. IFN-gamma and LPS augmented cell surface expression of Fas, but not tumour necrosis factor (TNF) receptor 1. Inhibitors of p38 mitogen-activated protein kinase (MAPK) prevented augmentation of Fas expression in IFN-gamma and LPS-treated END-D cells. IFN-gamma and LPS-treated END-D cells did not become susceptible to TNF-alpha or nitric oxide-mediated cytotoxicity. IFN-gamma and LPS thus appear to augment selectively Fas expression via activation of p38 MAPK and enhance Fas-mediated cell death in END-D cells. Furthermore, administration of IFN-gamma and LPS into mice induced in vivo expression of Fas on vascular endothelial cells and Fas ligand (FasL) on peripheral blood leucocytes. The relationship between enhancement of Fas-mediated cell death by IFN-gamma and LPS and the development of vascular endothelial injury is discussed.

Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression. Publishing Authors By Initials

N Koide,A Morikawa,G Tumurkhuu,J Dagvadorj,F Hassan,S Islam,Y Naiki,I Mori,T Yoshida,T Yokochi,N Koide,A Morikawa,G Tumurkhuu,J Dagvadorj,F Hassan,S Islam,Y Naiki,I Mori,T Yoshida,T Yokochi,N Koide,A Morikawa,G Tumurkhuu,J Dagvadorj,F Hassan,S Islam,Y Naiki,I Mori,T Yoshida,T Yokochi,

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Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression. Journal Published:

PUBLICATION TYPE: Research Support, Non-U.S. Gov

Journal: Clinical and experimental immunology

VOLUME: 150

Page Numbers: 553-60

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ISSN: 1365-2249

DAY: 27

MONTH: 09

YEAR: 2007

Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression. Information

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LANGUAGE: eng

NlmUniqueID: 57202

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Grant and Affiliation Information for Lipopolysaccharide and interferon-gamma enhance Fas-mediated cell death in mouse vascular endothelial cells via augmentation of Fas expression.

AFFILIATION: Department of Microbiology and Immunology, Aichi Medical University School of Medicine, Nagakute, Aichi, Japan. koide@aichi-med-u.ac.jp

Country: England

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MEDLINETA: Clin Exp Immunol

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